Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia

 
9783639103434: Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia

Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.

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Book Description Book Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | In Search of Therapeutic Targets for Cold Hyperesthesia | Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. | Format: Paperback | Language/Sprache: english | 180 pp. Bookseller Inventory # K9783639103434

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Book Description VDM Verlag Feb 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. 180 pp. Englisch. Bookseller Inventory # 9783639103434

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Book Description VDM Verlag Feb 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. 180 pp. Englisch. Bookseller Inventory # 9783639103434

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Book Description VDM Verlag Dr. Müller, 2010. Paperback. Book Condition: New. book. Bookseller Inventory # M3639103432

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Book Description VDM Verlag, 2010. Paperback. Book Condition: New. Language: English . Brand New Book. Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. Bookseller Inventory # KNV9783639103434

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