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Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia - Softcover
Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing.
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- PublisherVDM Verlag Dr. Müller
- Publication date2010
- ISBN 10 3639103432
- ISBN 13 9783639103434
- BindingPaperback
- Number of pages180
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Cold Thermal Processing in the Spinal Cord
Published by
VDM Verlag Dr. Müller
(2010)
ISBN 10: 3639103432
ISBN 13: 9783639103434
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. 180 pp. Englisch. Seller Inventory # 9783639103434
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Cold Thermal Processing in the Spinal Cord
Published by
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(2010)
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ISBN 13: 9783639103434
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Wrigley PaulMBBS, MM, PhD, FANZCA, FFPMANZCA has received numerous awards for research and clinical practice in Pain Medicine. He has senior clinical, teaching and research appointments at the Pain Management Research Centre, Royal. Seller Inventory # 4957712
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Cold Thermal Processing in the Spinal Cord : In Search of Therapeutic Targets for Cold Hyperesthesia
Published by
VDM Verlag Dr. Müller
(2010)
ISBN 10: 3639103432
ISBN 13: 9783639103434
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Taschenbuch
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. Seller Inventory # 9783639103434
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Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia
Published by
VDM Verlag Dr. Müller
(2010)
ISBN 10: 3639103432
ISBN 13: 9783639103434
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Paperback
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Book Description Paperback. Condition: Brand New. 180 pages. 8.66x5.91x0.41 inches. This item is printed on demand. Seller Inventory # zk3639103432
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