Imaging PET Reporter Transgenes in Living Subjects: Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes

 
9783639115178: Imaging PET Reporter Transgenes in Living Subjects: Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes

Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)/probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRG/PRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy.

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Dr. Yaghoubi is currently a research scientist at the department of Radiology, Molecular Imaging Program at Stanford University. He received his Bachelors in Science in Biomedical Engineering from University of Southern California in 1996 and his Ph.D. in Molecular and Medical Pharmacology from University of California, Los Angeles in 2002.

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Book Description Book Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | Methods for Non-invasive Monitoring of Therapeutic Transgene Expression in Mice and Humans Using Positron Emission Tomography Reporter Genes | Non-invasive imaging of transgene expression shouldsoon play a critical role in gene and adoptivecellular gene therapy clinical trials. Positronemission tomography (PET) reporter genes (PRG)/probes(PRP) are currently the most advanced technologiesavailable for imaging transgens in humans. PRGs canbe used to image the location, magnitude, and timevariation of the intensity of transgene expressionthroughout the whole body of a patient. This caneliminate the need for multiple biopsies, which arepotentially dangerous and yet do not provide acomplete picture of whole body transgene expressionat multiple time points. This dissertation providesdetails of several studies on direct and indirectimaging of therapeutic transgenes using multiplePRG/PRP systems in mice. Furthermore, it includes thedetails of the first study on the pharmacokinetics,dosimetry, and safety of an imaging reporter probe inhumans. Finally, a complete background on alternatemethods of imaging transgene expression has beenprovided, concluding with a discussion of potentialfuture applications of imaging in gene therapy. | Format: Paperback | Language/Sprache: english | 300 gr | 216 pp. Bookseller Inventory # K9783639115178

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Book Description VDM Verlag Feb 2009, 2009. Taschenbuch. Book Condition: Neu. Neuware - Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)/probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRG/PRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy. 216 pp. Englisch. Bookseller Inventory # 9783639115178

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Book Description VDM Verlag Feb 2009, 2009. Taschenbuch. Book Condition: Neu. Neuware - Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)/probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRG/PRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy. 216 pp. Englisch. Bookseller Inventory # 9783639115178

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Book Description VDM Verlag. Paperback. Book Condition: New. Paperback. 216 pages. Dimensions: 8.7in. x 5.9in. x 0.5in.Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRGPRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783639115178

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Book Description VDM Verlag, Germany, 2009. Paperback. Book Condition: New. Language: English . Brand New Book. Non-invasive imaging of transgene expression should soon play a critical role in gene and adoptive cellular gene therapy clinical trials. Positron emission tomography (PET) reporter genes (PRG)/probes (PRP) are currently the most advanced technologies available for imaging transgens in humans. PRGs can be used to image the location, magnitude, and time variation of the intensity of transgene expression throughout the whole body of a patient. This can eliminate the need for multiple biopsies, which are potentially dangerous and yet do not provide a complete picture of whole body transgene expression at multiple time points. This dissertation provides details of several studies on direct and indirect imaging of therapeutic transgenes using multiple PRG/PRP systems in mice. Furthermore, it includes the details of the first study on the pharmacokinetics, dosimetry, and safety of an imaging reporter probe in humans. Finally, a complete background on alternate methods of imaging transgene expression has been provided, concluding with a discussion of potential future applications of imaging in gene therapy. Bookseller Inventory # KNV9783639115178

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