Evaluation of Natural Antioxidants: The Antioxidant Activity of Phenolic Compounds in Relation to their Physicochemical Properties

 
9783639135190: Evaluation of Natural Antioxidants: The Antioxidant Activity of Phenolic Compounds in Relation to their Physicochemical Properties
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This book relates the physicochemical properties of phenolic compounds to their antioxidant activities. It focuses on the partitioning of phenolic compounds between hydrophilic and lipophilic environments and the relevance this has to their in vivo health effects. The partition coefficients (log P) of phenolic antioxidants were measured by RP-HPLC. The lipid Peroxidation Inhibition Capacity Assay (LPIC), based on using liposomes to simulate a cell membrane environment, was developed to measure the activity of antioxidants with a broad range of structures. The activities were correlated against several physicochemical parameters and used to derive a predictive model to calculate the LPIC activity. The LPIC activities also correlated well to published LDL inhibition activities but not to measured ORAC activities. These findings suggested that behaviours of antioxidants in the small unilamellar vesicles of the LPIC assay were similar to that in the LDL assay but not to the aqueous phase based ORAC assay. The LPIC assay may therefore be a better indicator of potential health benefits of antioxidants in the human body.

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About the Author:

Jingli Zhang received his PhD in 2004. During his PhD study, he investigated the health benefits of phytochemicals. Dr Zhang is currently working as a Senior Scientist at Plant & Food Research (New Zealand), where he investigates the health benefits of fruits and vegetables using chemical, cellular, animal and human models.

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Book Description Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | The Antioxidant Activity of Phenolic Compounds in Relation to their Physicochemical Properties | This book relates the physicochemical properties of phenolic compounds to their antioxidant activities. It focuses on the partitioning of phenolic compounds between hydrophilic and lipophilic environments and the relevance this has to their in vivo health effects. The partition coefficients (log P) of phenolic antioxidants were measured by RP-HPLC. The lipid Peroxidation Inhibition Capacity Assay (LPIC), based on using liposomes to simulate a cell membrane environment, was developed to measure the activity of antioxidants with a broad range of structures. The activities were correlated against several physicochemical parameters and used to derive a predictive model to calculate the LPIC activity. The LPIC activities also correlated well to published LDL inhibition activities but not to measured ORAC activities. These findings suggested that behaviours of antioxidants in the small unilamellar vesicles of the LPIC assay were similar to that in the LDL assay but not to the aqueous phase based ORAC assay. The LPIC assay may therefore be a better indicator of potential health benefits of antioxidants in the human body. | Format: Paperback | Language/Sprache: english | 312 gr | 228 pp. Seller Inventory # K9783639135190

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