The Effect of NO and CO on Cellular Iron Metabolism: A comparison of two diatomic cell signalling molecules

 
9783639146585: The Effect of NO and CO on Cellular Iron Metabolism: A comparison of two diatomic cell signalling molecules
View all copies of this ISBN edition:
 
 

Nitric oxide (NO) and carbon monoxide (CO) are toxic gases in the atmosphere that are usually associated with pollution. Surprisingly, both have been found to be synthesised within the body and have functions as signalling molecules. It has been shown that they actuate their signal by interacting with iron (Fe) in Fe-containing proteins. Fe is an obligate requirement for cells as many important enzymatic proteins utilise this element for redox activity. Activated macrophages produce large quantities of NO and it has been hypothesised that one of the cytotoxic mechanisms of activated macrophages is the NO crossing into the target cell and removing the Fe from the proteins and effluxing it from the cell. CO also interacts with Fe, but its effects on cellular Fe metabolism have not been examined in as great detail as NO has. This work has examined the effects of NO donors and CO gas and donors on cellular Fe metabolism. It describes the pathway NO utilises in its removal of Fe from cells and compares these results with CO. It indicates that although both molecules interact with Fe they have different effects on cellular Fe metabolism.

"synopsis" may belong to another edition of this title.

About the Author:

Dr Watts graduated with a PhD from the University of New South Wales in 2004. He currently holds a Peter Doherty Research Fellowship from the National Health and Medical Research Council Australia (NHMRC). Prof Richardson is Professor of Cancer Cell Biology and NHMRC Senior Principal Research Fellow at the University of Sydney, Australia.

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 90.00
US$ 66.33

Convert currency

Shipping: US$ 9.86
From United Kingdom to U.S.A.

Destination, rates & speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Ralph Watts (author)
Published by VDM Verlag 2009-04-30 (2009)
ISBN 10: 3639146581 ISBN 13: 9783639146585
New paperback Quantity Available: > 20
Seller:
Blackwell's
(Oxford, OX, United Kingdom)
Rating
[?]

Book Description VDM Verlag 2009-04-30, 2009. paperback. Condition: New. Seller Inventory # 9783639146585

More information about this seller | Contact this seller

Buy New
US$ 66.33
Convert currency

Add to Basket

Shipping: US$ 9.86
From United Kingdom to U.S.A.
Destination, rates & speeds

2.

Watts, Ralph
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Quantity Available: 1
Seller:
Rating
[?]

Book Description Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | A comparison of two diatomic cell signalling molecules | Nitric oxide (NO) and carbon monoxide (CO) are toxic gases in the atmosphere that are usually associated with pollution. Surprisingly, both have been found to be synthesised within the body and have functions as signalling molecules. It has been shown that they actuate their signal by interacting with iron (Fe) in Fe-containing proteins. Fe is an obligate requirement for cells as many important enzymatic proteins utilise this element for redox activity. Activated macrophages produce large quantities of NO and it has been hypothesised that one of the cytotoxic mechanisms of activated macrophages is the NO crossing into the target cell and removing the Fe from the proteins and effluxing it from the cell. CO also interacts with Fe, but its effects on cellular Fe metabolism have not been examined in as great detail as NO has. This work has examined the effects of NO donors and CO gas and donors on cellular Fe metabolism. It describes the pathway NO utilises in its removal of Fe from cells and compares these results with CO. It indicates that although both molecules interact with Fe they have different effects on cellular Fe metabolism. | Format: Paperback | Language/Sprache: english | 274 gr | 196 pp. Seller Inventory # K9783639146585

More information about this seller | Contact this seller

Buy New
US$ 74.80
Convert currency

Add to Basket

Shipping: US$ 3.21
From Germany to U.S.A.
Destination, rates & speeds

3.

Ralph Watts
Published by VDM Verlag (2009)
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description VDM Verlag, 2009. PAP. Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # IQ-9783639146585

More information about this seller | Contact this seller

Buy New
US$ 85.53
Convert currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, rates & speeds

4.

Watts, Ralph
Published by VDM Verlag (2016)
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description VDM Verlag, 2016. Paperback. Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Seller Inventory # ria9783639146585_lsuk

More information about this seller | Contact this seller

Buy New
US$ 86.38
Convert currency

Add to Basket

Shipping: US$ 5.07
From United Kingdom to U.S.A.
Destination, rates & speeds

5.

Ralph Watts
Published by VDM Verlag (2009)
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description VDM Verlag, 2009. PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # LQ-9783639146585

More information about this seller | Contact this seller

Buy New
US$ 81.06
Convert currency

Add to Basket

Shipping: US$ 11.83
From United Kingdom to U.S.A.
Destination, rates & speeds

6.

Ralph Watts
Published by VDM Verlag Dr. Müller
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Taschenbuch Quantity Available: 1
Seller:
BuchWeltWeit Inh. Ludwig Meier e.K.
(Bergisch Gladbach, Germany)
Rating
[?]

Book Description VDM Verlag Dr. Müller. Taschenbuch. Condition: Neu. Neuware - Nitric oxide (NO) and carbon monoxide (CO) are toxic 196 pp. Englisch. Seller Inventory # 9783639146585

More information about this seller | Contact this seller

Buy New
US$ 81.73
Convert currency

Add to Basket

Shipping: US$ 19.99
From Germany to U.S.A.
Destination, rates & speeds

7.

Ralph Watts
Published by VDM Verlag Dr. Müller
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Taschenbuch Quantity Available: 1
Seller:
Rheinberg-Buch
(Bergisch Gladbach, Germany)
Rating
[?]

Book Description VDM Verlag Dr. Müller. Taschenbuch. Condition: Neu. Neuware - Nitric oxide (NO) and carbon monoxide (CO) are toxic 196 pp. Englisch. Seller Inventory # 9783639146585

More information about this seller | Contact this seller

Buy New
US$ 81.73
Convert currency

Add to Basket

Shipping: US$ 19.99
From Germany to U.S.A.
Destination, rates & speeds

8.

Ralph Watts
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Quantity Available: 5
Seller:
ReadWhiz
(Portland, OR, U.S.A.)
Rating
[?]

Book Description Condition: New. Seller Inventory # ria9783639146585_ing

More information about this seller | Contact this seller

Buy New
US$ 105.04
Convert currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, rates & speeds

9.

Ralph Watts
Published by VDM Verlag (2009)
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Paperback Quantity Available: 1
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description VDM Verlag, 2009. Paperback. Condition: New. Seller Inventory # DADAX3639146581

More information about this seller | Contact this seller

Buy New
US$ 105.21
Convert currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, rates & speeds

10.

Ralph Watts
Published by VDM Verlag Dr. Müller
ISBN 10: 3639146581 ISBN 13: 9783639146585
New Taschenbuch Quantity Available: 1
Print on Demand
Seller:
AHA-BUCH GmbH
(Einbeck, Germany)
Rating
[?]

Book Description VDM Verlag Dr. Müller. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - Nitric oxide (NO) and carbon monoxide (CO) are toxic 196 pp. Englisch. Seller Inventory # 9783639146585

More information about this seller | Contact this seller

Buy New
US$ 81.73
Convert currency

Add to Basket

Shipping: US$ 34.42
From Germany to U.S.A.
Destination, rates & speeds

There are more copies of this book

View all search results for this book