LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function

 
9783639150483: LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function

This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG). Long-term potentiation (LTP) is a well- known model for studying strengthening of synaptic plasticity. In this study, LTP was induced in the DG by intrahippocampal infusion of brain-derived neurotrophic factor (BDNF-LTP). Alternatively, LTP was induced at medial perforant path-granule cell synapses by high frequency stimulation (HFS-LTP). The aim of the study was investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) as well as changes in activation of the translation factors eIF4E (eukaryotic initiation factor 4E) and eEF2 (eukaryotic elongation factor-2) during LTP. We have demonstrated rapid activation of both translation factors and upregulation of Arc protein during BDNF-LTP. Additionally, an approach based on intrahippocampal infusion of Arc antisense oligodeoxynucleotides showed the importance of sustained Arc translation for the maintenance of both BDNF-LTP and HFS-LTP during a restricted time window.

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Dr. Kanhema's field of expertise is neuroscience. She undertook her PhD at the University of Bergen, Norway and focused her research on the molecular mechanisms of synaptic plasticity in the rat hippocampus. Dr. Kanhema is currently senior engineer and manager of Prof. Clive Bramham's lab at the Dept.of Biomedicine, University of Bergen.

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Book Description Book Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | BDNF signaling, translation control, and gene function | This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG). Long-term potentiation (LTP) is a well-known model for studying strengthening of synaptic plasticity. In this study, LTP was induced in the DG by intrahippocampal infusion of brain-derived neurotrophic factor (BDNF-LTP). Alternatively, LTP was induced at medial perforant path-granule cell synapses by high frequency stimulation (HFS-LTP).The aim of the study was investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) as well as changes in activation of the translation factors eIF4E (eukaryotic initiation factor 4E) and eEF2 (eukaryotic elongation factor-2) during LTP.We have demonstrated rapid activation of both translation factors and upregulation of Arc protein during BDNF-LTP. Additionally, an approach based on intrahippocampal infusion of Arc antisense oligodeoxynucleotides showed the importance of sustained Arc translation for the maintenance of both BDNF-LTP and HFS-LTP during a restricted time window. | Format: Paperback | Language/Sprache: english | 185 gr | 132 pp. Bookseller Inventory # K9783639150483

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Book Description VDM Verlag Jul 2009, 2009. Taschenbuch. Book Condition: Neu. Neuware - This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG). Long-term potentiation (LTP) is a well- known model for studying strengthening of synaptic plasticity. In this study, LTP was induced in the DG by intrahippocampal infusion of brain-derived neurotrophic factor (BDNF-LTP). Alternatively, LTP was induced at medial perforant path-granule cell synapses by high frequency stimulation (HFS-LTP). The aim of the study was investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) as well as changes in activation of the translation factors eIF4E (eukaryotic initiation factor 4E) and eEF2 (eukaryotic elongation factor-2) during LTP. We have demonstrated rapid activation of both translation factors and upregulation of Arc protein during BDNF-LTP. Additionally, an approach based on intrahippocampal infusion of Arc antisense oligodeoxynucleotides showed the importance of sustained Arc translation for the maintenance of both BDNF-LTP and HFS-LTP during a restricted time window. 132 pp. Englisch. Bookseller Inventory # 9783639150483

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Book Description VDM Verlag Jul 2009, 2009. Taschenbuch. Book Condition: Neu. Neuware - This book illustrates some of the various molecular mechanisms underlying synaptic plasticity in a subfield of the rat hippocampus called dentate gyrus (DG). Long-term potentiation (LTP) is a well- known model for studying strengthening of synaptic plasticity. In this study, LTP was induced in the DG by intrahippocampal infusion of brain-derived neurotrophic factor (BDNF-LTP). Alternatively, LTP was induced at medial perforant path-granule cell synapses by high frequency stimulation (HFS-LTP). The aim of the study was investigation of transcriptional and translational changes of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) as well as changes in activation of the translation factors eIF4E (eukaryotic initiation factor 4E) and eEF2 (eukaryotic elongation factor-2) during LTP. We have demonstrated rapid activation of both translation factors and upregulation of Arc protein during BDNF-LTP. Additionally, an approach based on intrahippocampal infusion of Arc antisense oligodeoxynucleotides showed the importance of sustained Arc translation for the maintenance of both BDNF-LTP and HFS-LTP during a restricted time window. 132 pp. Englisch. Bookseller Inventory # 9783639150483

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