INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITH NUCLEIC ACIDS: An approach to study interactions between natural compounds with nucleic acids and synthesis of flavonoid derivatives

 
9783639157673: INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITH NUCLEIC ACIDS: An approach to study interactions between natural compounds with nucleic acids and synthesis of flavonoid derivatives
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Across the world, different diseases have been treated with herbal extracts, based on common and empiric knowledge. The process of identification of the active compounds and their synthesis, optimisation and development for new drug candidates appropriate for clinical use is described as Medicinal Chemistry; a discipline merging chemistry and pharmacology. This monograph describes a group of active ingredients from herbal medicines, as a foundation for the development of new anticancer drugs. Interactions between with genomic DNA, synthetic polynucleotides and higher order DNA isoforms (triple and quadruple helical forms) have been studied. Rational drug design has been also employed during this project to elucidate the mode of binding and novel compounds have been synthesized to provide precise structure-activity related studies resulting in a second generation of chemotherapeutic anticancer agents with improved properties. This book provides information and protocols for studying drug-DNA interactions using spectroscopical and biological techniques; synthesis of flavonoids and the principles to explore the use of Quantitative Structure Activity Relationship Studies.

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Chemistry Degree, Universidad del Salvador, Argentina, 1997. Specialisation in Protein Biochemistry, Institute Leloir, Argentina, 2001. PhD in Medicinal Chemistry, Open University, United Kingdom, 2005. Postdoctoral fellowship in Biophysical Studies, Brown Cancer Centre, USA, 2008. Sr Scientist, ADMETox Lab., Peakdale Mol., United Kingdom, present.

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Book Description Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | An approach to study interactions between natural compounds with nucleic acids and synthesis of flavonoid derivatives | Across the world, different diseases have beentreated with herbal extracts, based on common andempiric knowledge. The process of identification ofthe active compounds and their synthesis,optimisation and development for new drug candidatesappropriate for clinical use is described asMedicinal Chemistry; a discipline merging chemistryand pharmacology. This monograph describes a group of activeingredients from herbal medicines, as a foundationfor the development of new anticancer drugs.Interactions between with genomic DNA, syntheticpolynucleotides and higher order DNA isoforms (tripleand quadruple helical forms) have been studied.Rational drug design has been also employed duringthis project to elucidate the mode of binding andnovel compounds have been synthesized to provideprecise structure-activity related studies resultingin a second generation of chemotherapeutic anticanceragents with improved properties. This book provides information and protocols forstudying drug-DNA interactions using spectroscopicaland biological techniques; synthesis of flavonoidsand the principles to explore the use of QuantitativeStructure Activity Relationship Studies. | Format: Paperback | Language/Sprache: english | 352 gr | 260 pp. Seller Inventory # K9783639157673

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Book Description VDM Verlag Mai 2009, 2009. Taschenbuch. Condition: Neu. Neuware - Across the world, different diseases have been treated with herbal extracts, based on common and empiric knowledge. The process of identification of the active compounds and their synthesis, optimisation and development for new drug candidates appropriate for clinical use is described as Medicinal Chemistry; a discipline merging chemistry and pharmacology. This monograph describes a group of active ingredients from herbal medicines, as a foundation for the development of new anticancer drugs. Interactions between with genomic DNA, synthetic polynucleotides and higher order DNA isoforms (triple and quadruple helical forms) have been studied. Rational drug design has been also employed during this project to elucidate the mode of binding and novel compounds have been synthesized to provide precise structure-activity related studies resulting in a second generation of chemotherapeutic anticancer agents with improved properties. This book provides information and protocols for studying drug-DNA interactions using spectroscopical and biological techniques; synthesis of flavonoids and the principles to explore the use of Quantitative Structure Activity Relationship Studies. 260 pp. Englisch. Seller Inventory # 9783639157673

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Book Description VDM Verlag Mai 2009, 2009. Taschenbuch. Condition: Neu. Neuware - Across the world, different diseases have been treated with herbal extracts, based on common and empiric knowledge. The process of identification of the active compounds and their synthesis, optimisation and development for new drug candidates appropriate for clinical use is described as Medicinal Chemistry; a discipline merging chemistry and pharmacology. This monograph describes a group of active ingredients from herbal medicines, as a foundation for the development of new anticancer drugs. Interactions between with genomic DNA, synthetic polynucleotides and higher order DNA isoforms (triple and quadruple helical forms) have been studied. Rational drug design has been also employed during this project to elucidate the mode of binding and novel compounds have been synthesized to provide precise structure-activity related studies resulting in a second generation of chemotherapeutic anticancer agents with improved properties. This book provides information and protocols for studying drug-DNA interactions using spectroscopical and biological techniques; synthesis of flavonoids and the principles to explore the use of Quantitative Structure Activity Relationship Studies. 260 pp. Englisch. Seller Inventory # 9783639157673

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