The actin cytoskeleton and macrophages: Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages

 
9783639169041: The actin cytoskeleton and macrophages: Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages
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Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. The actin cytoskeleton stands central in the process of cell migration. CSF-1 is an important physiological chemoattractant for macrophages. The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood.In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages.We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2.Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches.

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Wassim G. Aboukheir, PhD: studied cell biology at Albert Einstein College of Medicine (NYC). Scientist at the National Institutes of Health (NIH), MD.

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Book Description Condition: New. Publisher/Verlag: VDM Verlag Dr. Müller | Function and regulation of the WASp/WAVE family member, WAVE2, in macrophages | Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. The actin cytoskeleton stands central in the process of cell migration. CSF-1 is an important physiological chemoattractant for macrophages. The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood.In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages.We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2.Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches. | Format: Paperback | Language/Sprache: english | 144 pp. Seller Inventory # K9783639169041

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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Condition: Neu. Neuware - Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. The actin cytoskeleton stands central in the process of cell migration. CSF-1 is an important physiological chemoattractant for macrophages. The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood.In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages.We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2.Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches. 144 pp. Englisch. Seller Inventory # 9783639169041

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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Condition: Neu. Neuware - Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. The actin cytoskeleton stands central in the process of cell migration. CSF-1 is an important physiological chemoattractant for macrophages. The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood.In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages.We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2.Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches. 144 pp. Englisch. Seller Inventory # 9783639169041

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Book Description VDM Verlag Jun 2009, 2009. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - Cell migration is a fundamental process required for 144 pp. Englisch. Seller Inventory # 9783639169041

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Book Description VDM Verlag, Russian Federation, 2012. Paperback. Condition: New. Language: English . Brand New Book. Cell migration is a fundamental process required for normal immune system function,embryonic development,and tissue repair. Nevertheless,this process also contributes to the pathogenesis of several diseases,such as chronic inflammatory disease and tumor cell invasion. The actin cytoskeleton stands central in the process of cell migration. CSF-1 is an important physiological chemoattractant for macrophages. The mechanisms by which CSF-1 affects actin cytoskeleton and induces macrophage migration are not fully understood.In particular,very little is known regarding the role of WAVE2 protein in response to CSF-1. We have identified for the first time WAVE2 as a pivotal factor required for CSF-1-induced cell migration in macrophages.We have also suggested a model for the regulation of WAVE2 activity in vivo in which IRSp53 plays a central role in mediating the interaction between Rac1 and WAVE2.Dissecting the fundamental mechanisms underlying WAVE2-dependent CSF-1-induced cell migration is important for understanding macrophage-mediated diseases,like tumor metastasis, and therefore holds the promise of newly effective therapeutic approaches. This book was created using print-on-demand technology. Seller Inventory # KNV9783639169041

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