Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases .
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The text of all chapters is organized in a logical and capacious manner. Although the book is an assemblage of parts written by different authors, the overall uniformity of the work is commendable and the readability is good.
The book educates us about a fascinating, but also difficult, area. It is one of the few books that shows the greatest assortment and chemical details about contrasts agents of MRI.
- EUROPEAN RADIOLOGY
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Book Description Springer, 2010. Paperback. Book Condition: NEW. 9783642075964 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Bookseller Inventory # HTANDREE0350086
Book Description Springer, 2010. Book Condition: New. This item is printed on demand for shipment within 3 working days. Bookseller Inventory # LP9783642075964
Book Description Springer, 2010. Paperback. Book Condition: Brand New. softcover reprint of hardcover 1st ed. 2002 edition. 249 pages. 9.50x6.00x0.62 inches. In Stock. Bookseller Inventory # __3642075967