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-A landmark in the continuously changing world of drugs
-Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
-Of use for government institutions and committees working on official guidelines for drug evaluation worldwide
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Hans Gerhard Vogel (1927–2011)
H. Gerhard Vogel studied Pharmacy and Medicine at the Universities Erlangen and Tübingen (Germany). He received his Licensure as a Pharmacist in 1952 and as a Physician in 1956. His Doctorate in Medicine was gained in 1955. In 1963 he was designated a Fachpharmakologe DPhG. In 1967 he became Associate Professor in Pharmacology and Toxicology of the Department of Medicine, University of Marburg. In 1970 he was acknowledged as a Specialist for Pharmacology (Arzt für Pharmakologie). From 1972 he taught students of Medicine, Pharmacy and Biology as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Marburg and from 1979 as an Honorary Professor in Pharmacology and Toxicology of the Faculty of Medicine, University of Frankfurt. After working as a resident in medicine in a city hospital, he joined the Department of Pharmacology of Farbwerke Hoechst AG, Frankfurt as a pharmacologist and endocrinologist in 1958. In 1969 he was made Director of the Department of Pharmacology at Hoechst, in 1977 Head of Pharma Research Experimental Medicine, in 1980 Head of Pharma Research, Preclinical Evaluation and Development, and in 1989 Head of the Decision Board on Pharmaceutical Development.
His scientific work was devoted to elaboration of new pharmacological methods, pharmacology of plant extracts from various countries, pharmacology of steroid hormones, pharmacology of peptide hormones, pharmacology of cardiac glycosides, biomechanics and biochemistry of connective tissue, experimental gerontology, experimental dermatology, development procedures for pharmaceutical products. He published more than 160 papers, mainly on new pharmacological methods, endocrinology, especially peptide endocrinology, biomechanics and biochemistry of connective tissue, such as skin and bone, and on other topics. He was a member of many international and national scientific societies, such as The New York Academy of Science, American Association for the Advancement of Science, German Society of Experimental and Clinical Pharmacology and Toxicology, International Society for Bioengineering and the Skin, European Association for the Study of Diabetes, German Society of Endocrinology, German Society of Diabetology, German Society Connective Tissue Research, German–Chinese Society of Medicine. He was a co-editor and contributor to several scientific textbooks. In 1997 he published together with Wolfgang H. Vogel the book Drug Discovery and Evaluation. Pharmacological Assays (Springer-Verlag), which appeared in a second completely revised, updated and enlarged edition with many contributions by his colleagues in 2002. A third edition was published in 2008.
Editorial Board:Franz Jakob Hock
Franz Jakob Hock received his Ph.D. degree (Sc.D.) in Zoology at the Institute of Neuroethology and Biocybernetics at the University of Kassel, Germany. He joined the Department of Pharmacology of the pharmaceutical company Hoechst AG in 1976. He initially worked on methods in general pharmacology and nephrology, before becoming head of a laboratory devoted to pharmacological methods for drugs influencing memory and learning. He was then appointed Head of the Laboratory of General and Safety Pharmacology at the Frankfurt site of Aventis Pharma Deutschland GmbH. He received the degree of Fachpharmakologe DGPT (“certified expert pharmacology”) in 1981. In 1983 he spent a sabbatical year at the University of California, Irvine, at the Center for the Neurobiology of Learning and Memory (Director Prof. Dr. James L. McGaugh). He lectured for several years to students in Biology at the University of Kassel and the Technical University Darmstadt. He has published over 100 original papers on methods in Pharmacology and on new compounds. He is currently a member of the Task Force General/Safety Pharmacology German/Swiss Pharmaceutical Companies. He served several times as a member of the program committee of the Safety Pharmacology Society. He is a member of several domestic and international scientific societies. He now works as a consultant in pharmaceutical business development.Jochen Maas
Jochen Maas is head of the Research and Development organization of the Diabetes Division within Sanofi and simultaneously General Manager Research & Development Germany. Previously he was head of the Drug Metabolism and Pharmacokinetics departments of Aventis in Frankfurt and in Paris. Educated at the universities of Heidelberg, Munich and Zurich, his background includes degrees in Biology and Veterinarian Medicine. During his studies and researching for his thesis at the “Gesellschaft für Strahlen- und Umweltforschung“ in Munich-Neuherberg he collected his first experiences in Pharmacokinetics and in working with radiolabeled compounds. After a short period as assistant veterinarian in an animal hospital he joined the former Hoechst AG as Laboratory Head in 1992, performing various kinds of animal studies with radiolabeled isotopes in the life-science area of pharmaceutics, veterinarian medicine and crop science. During this time he completed his education as a specialist for Radiology. Following the break-up of the different parts of the company he became Section Head, responsible not only for carrying out but also for the analysis, evaluation and assessment of all kinds of pharmacokinetic and toxicokinetic animal studies. He took over the responsibility for the complete Drug Metabolism and Pharmacokinetics Department in Frankfurt in 2000. His activities ranged from in-silico approaches at very early stages of the value chain, in-vitro studies, and in vivo animal studies up to Phase I, II and III clinical studies. The whole scope of these activities from early research to late development is included in the pharmacokinetic part of this book. In 2003 he was appointed Head of Drug Metabolism and Pharmacokinetics in Paris working simulataneously in France and Germany. The main objective of his work was an intensive knowledge transfer from early parts of the value chain (“Research”) to the late stages (“Development”) and vice versa across the different disciplines. Today, one of his major interests is to bring together pharmacodynamic and pharmacokinetic research activities and to combine the obtained knowledge with safety aspects resulting in lower attrition rates at the later stage of the development.Dieter Mayer
Dieter Mayer studied veterinary medicine at the University of Munich, Germany. Thereafter, he worked on a thesis on biochemical mechanisms of heavy metal intoxication at the Institute of Pharmacology and Toxicology at the Ludwigs-Maximilian-University of Munich. In 1975 he joined Hoechst AG Frankfurt, Germany. He worked there at the Institute of Industrial Toxicology and was in charge of the safety assessment of Acesulfam, an artificial sweetener. Further projects consisted of fluorocarbons as replacements for chlorofluorocarbons. He contributed to the development of several pesticides.Dieter Mayer was a member of the German MAK (TLV) committee for about 12 years. He worked at the University of Davis, California and at the Centre International de Toxicologie (affiliation of Hoechst AG), Evreux, France, where he held the position of Scientific Director. In 1986 he became Head of the central toxicology department at Hoechst AG. This entailed responsibility for the entire Hoechst portfolio, and hence also for pharmaceuticals. He was involved in the successful development of anti-infectives, cardiovascular drugs, several insulins, CNS drugs and anti-rheumatics. In 1998 he was promoted to Vice President of Lead Optimization (Toxicology, DMPK and clin. Pharmacology).Prof. Mayer has been teaching toxicology at the University of Frankfurt since 1991 and has authored more than 90 scientific articles, abstracts and oral presentations. Today Dieter Mayer is a Consultant for the global pharmaceutical industry and is a member of the Advisory Board of National German Research Associations.
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