TOR and GSK3 in the ciliate Paramecium tetraurelia: Target of Rapamycin and Glycogen Synthase Kinase 3 pathway orthologs and their regulation of ciliary length/assembly

 
9783659128356: TOR and GSK3 in the ciliate Paramecium tetraurelia: Target of Rapamycin and Glycogen Synthase Kinase 3 pathway orthologs and their regulation of ciliary length/assembly
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Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent.

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I have received my graduate degree in cell and molecular biology at the University of Vermont, in the laboratory of Dr. Judith Van Houten, where I investigated Mammalian Target of Rapamycin signaling pathways. Presently, I work as a researcher for the proteomics group at the Broad Institute of MIT and Harvard.

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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Target of Rapamycin and Glycogen Synthase Kinase 3 pathway orthologs and their regulation of ciliary length/assembly | Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. | Format: Paperback | Language/Sprache: english | 340 pp. Seller Inventory # K9783659128356

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. 340 pp. Englisch. Seller Inventory # 9783659128356

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. 340 pp. Englisch. Seller Inventory # 9783659128356

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. 340 pp. Englisch. Seller Inventory # 9783659128356

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Book Description LAP Lambert Academic Publishing, Germany, 2012. Paperback. Condition: New. Aufl.. Language: English. Brand new Book. Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag A/B, Rag C/D, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and /or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. Seller Inventory # AAV9783659128356

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Book Description LAP Lambert Academic Publishing. Paperback. Condition: New. 340 pages. Dimensions: 8.7in. x 5.9in. x 0.8in.Target of rapamycin (TOR) is a serine threonine kinase that regulates cellular processes in response to the stresses and nutrients in the environment. We investigated TOR signaling pathway in the ciliate Paramecium tetraurelia (P. tetraurelia). Using BLAST (Basic Local Alignment Search Tool) we identified orthologs of the mammalian TOR, LST8, Akt, Rheb, Rag AB, Rag CD, SNAT2, Tap42, S6K, PKA and GSK3 in the P. tetraurelia. With RNA interference technique we established that depletion of these orthologs reduced cellular proliferation and arrested cells between G1 and S stages of the cell cycle. Furthermore, GSK3 depletion produced round looking cells with short, sparse cilia, and GSK3 was localized to the pellicle and cilia of P. tetraurelia. In addition to these investigations, we determined that inhibition of PKA with H89 prevented re-growth of cilia in de-ciliated cells. Our results possibly suggest that GSK3 and PKA work together in the regulation of ciliary length and or assembly in P. tetraurelia. We also hypothesize that these regulations are TOR dependent. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Seller Inventory # 9783659128356

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