Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling: Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling- with a pre-clinical application

 
9783659129186: Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling: Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling- with a pre-clinical application

Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment.

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About the Author:

Mr. Dheeraj Gopu has obtained his Master's degree with Pharmacology specialization from Kakatiya University, Warangal, India. He specializes in Pharmacokinetic/Pharmacodynamic modeling of various classes of drugs. Presently he is working as a Assistant Professor in the Department of Pharmacology in Vaagdevi College of Pharmacy, K.U. Warangal, India

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Pharmacokinetic / Pharmacodynamic (PK/PD) Modelling- with a pre-clinical application | Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment. | Format: Paperback | Language/Sprache: english | 139 gr | 220x150x5 mm | 92 pp. Bookseller Inventory # K9783659129186

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Book Condition: Neu. Neuware - Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment. 92 pp. Englisch. Bookseller Inventory # 9783659129186

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Book Condition: Neu. Neuware - Pharmacokinetic-Pharmacodynamic (PK/PD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK and/or PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PK/PD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PK/PD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment. 92 pp. Englisch. Bookseller Inventory # 9783659129186

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Book Description LAP Lambert Academic Publishing. Paperback. Book Condition: New. Paperback. 92 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Pharmacokinetic-Pharmacodynamic (PKPD) modeling is scientific mathematical tool which integrates relationship PK model to that of PD model and a statistical model (particularly, the intra- and inter-individual variability of PK andor PD origin). PK-PD approach is used from initial preclinical stage to last clinical phases for exploring the concentration-effect relationships executed using various approaches, such as steady state concentrations versus non-steady state concentrations models and parametric versus nonparametric models. Basing on the concentration-response invariant data basic models such as fixed-effect, linear, log-linear, Emax and sigmaoid Emax models are used. But in case of time-concentration and time-response variant conditions effect compartment, acute tolerance, sensitization and physiological indirect response models have been used. PKPD modeling can be used as an applied science tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. Still limits of PKPD approaches include the development of appropriate models, the validity of surrogate endpoints, and the acceptance of these models in a regulatory environment. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783659129186

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