Magnetic resonance imaging of the cerebral blood volume: Characterization of experimental brain tumor neovascularization

 
9783659146114: Magnetic resonance imaging of the cerebral blood volume: Characterization of experimental brain tumor neovascularization
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Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3%) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2*-based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient κ (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability.

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Teodora-Adriana Perles-Barbacaru was born in Romania and grew up in Germany. She is a medical doctor and practiced in India, Switzerland and Israel. She studied fundamental physics and astrophysics and got her PhD in neuroimaging in France. After working in California she now teaches neuroscience and works in oncological imaging research in France

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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Characterization of experimental brain tumor neovascularization | Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3%) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2 -based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. | Format: Paperback | Language/Sprache: english | 452 pp. Seller Inventory # K9783659146114

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3%) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2 -based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. 452 pp. Englisch. Seller Inventory # 9783659146114

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Teodora-Adriana Perles-Barbacaru
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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3%) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2 -based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. 452 pp. Englisch. Seller Inventory # 9783659146114

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Book Description LAP Lambert Academic Publishing Jun 2012, 2012. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3%) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2 -based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. 452 pp. Englisch. Seller Inventory # 9783659146114

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Teodora-Adriana Perles-Barbacaru, Hana Lahrech
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Book Description LAP Lambert Academic Publishing, Germany, 2012. Paperback. Condition: New. Aufl.. Language: English . Brand New Book ***** Print on Demand *****.Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2.35 T (CBVf: 2 to 3 ) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2*-based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. Seller Inventory # AAV9783659146114

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Book Description LAP Lambert Academic Publishing. Paperback. Condition: New. 452 pages. Dimensions: 8.7in. x 5.9in. x 1.0in.Cerebral blood volume fraction (CBVf) mapping by magnetic resonance imaging (MRI) can provide information about tumor angiogenesis. The Rapid Steady State T1 (RSST1) MRI method, based on a two-compartment model, intra- and extravascular, and on the longitudinal relaxivity of intravascular contrast agents (CAs), is developed and validated on healthy rats at 2. 35 T (CBVf: 2 to 3) using Gd-DOTA, approved for clinical use, and the experimental CA P760. Gd-ACX and SINEREM are evaluated for their blood pool properties in two rat glioma models C6 and RG2. The CBVf measures in tumor tissue are confirmed by histologic vascular morphometric analysis and were compared with those obtained by a DeltaR2-based steady state method using the same SINEREM injection. In case of CA extravasation, such as occurs in tumor tissue with Gd-DOTA, the CBVf along with the transfer coefficient (related to the endothelial permeability) were obtained by pharmacokinetic two-compartment analysis of dynamic RSST1 acquisitions. In conclusion, the RSST1 method in conjunction with appropriate CAs can be used for longitudinal angiogenesis studies to quantify the CBVf and the vascular permeability. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Seller Inventory # 9783659146114

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