Formulation of Bilayered Floating Tablets of Atorvastatin and Niacin: Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin

 
9783659268595: Formulation of Bilayered Floating Tablets of Atorvastatin and Niacin: Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin
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In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia.

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My interest to develop a dosage form by applying different formulation and process techniques according to drug properties gave the basis for the present research work. Thanks for Lord Ganesh, my parents,Laxman Murthy K & DR Reddy's Laboratories for their kind support.

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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Formulation and Evaluation of Bilayered Floating Tablets of Atorvastatin Calcium and Niacin | In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia. | Format: Paperback | Language/Sprache: english | 148 pp. Seller Inventory # K9783659268595

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Puthoori Haripriya
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Book Description LAP Lambert Academic Publishing Okt 2012, 2012. Taschenbuch. Condition: Neu. Neuware - In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia. 148 pp. Englisch. Seller Inventory # 9783659268595

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Puthoori Haripriya
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Book Description LAP Lambert Academic Publishing Okt 2012, 2012. Taschenbuch. Condition: Neu. Neuware - In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia. 148 pp. Englisch. Seller Inventory # 9783659268595

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Puthoori Haripriya
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Book Description LAP Lambert Academic Publishing Okt 2012, 2012. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia. 148 pp. Englisch. Seller Inventory # 9783659268595

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Puthoori Haripriya, T. E. G. K. Murthy, Atul Kaushik
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Book Description LAP Lambert Academic Publishing, 2012. Paperback. Condition: New. Language: English . Brand New Book. In general, Cardiovascular Disease (CVD) is mainly associated with abnormal cholesterol levels (Hypercholesterolemia) in which there are increased levels of LDL and decreased levels of HDL in blood. This leads to atherosclerosis that later leads to myocardial infarction, stroke, and peripheral disease. Hence control of blood cholesterol levels is very much important to reduce the risk of CVD. In the present investigation, Atorvastatin Calcium (AT)(BCS Class II drug) an anti-hyperlipidemic agent belongs to the class Statins was formulated as an immediate release layer by using different excipients to improve the rate of dissolution. This reduces the levels of LDL and triglycerides in the blood to a major extent. On the other hand, Niacin (NA), a vitamin B3 was formulated as floating sustained release layer by using different combination of polymers to get desired drug release. Niacin in higher concentrations is used to treat hypercholesterolemia by reducing the levels of LDL, triglycerides to some extent and increases the levels of HDL to a major extent. Hence,the combination of AT and NA was found to be more beneficial than individual drugs in the treatment of hypercholesterolemia. Seller Inventory # KNV9783659268595

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