Homology Modeling of Dopamine Receptors and Docking Study: Structure Based Drug Design

 
9783659277016: Homology Modeling of Dopamine Receptors and Docking Study: Structure Based Drug Design

Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules.

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About the Author:

Manish K. Gupta (M. Pharm., Ph.D.) is working as an associate professor at Dept. of Pharma. Chemistry, ISF College of Pharmacy, Moga, India. His research interests include ligand and structure based drug design, high dimensional QSAR studies and theoretical aspects of drug design. He has published several research papers in peer-reviewed journals.

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Structure Based Drug Design | Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules. | Format: Paperback | Language/Sprache: english | 80 pp. Bookseller Inventory # K9783659277016

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Book Description LAP Lambert Academic Publishing Okt 2012, 2012. Taschenbuch. Book Condition: Neu. Neuware - Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules. 80 pp. Englisch. Bookseller Inventory # 9783659277016

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Book Description LAP Lambert Academic Publishing Okt 2012, 2012. Taschenbuch. Book Condition: Neu. Neuware - Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules. 80 pp. Englisch. Bookseller Inventory # 9783659277016

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Book Description LAP Lambert Academic Publishing. Paperback. Book Condition: New. Paperback. 80 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i. e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783659277016

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Book Description LAP Lambert Academic Publishing, United States, 2012. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules. Bookseller Inventory # AAV9783659277016

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