Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form: Analytical Method Development & Validation

 
9783659425288: Estimation of Ceftazidime and Tazobactam in an Injectable Dosage Form: Analytical Method Development & Validation

A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 µg/mL and 10-60 µg/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method.

"synopsis" may belong to another edition of this title.

About the Author:

M.Pharm(Quality Assurance) ,Shri Sarvajanik Pharmacy College, Mehsana affiliated to Gujarat Technological University, Ahmedabad.

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 66.00
US$ 51.61

Convert Currency

Shipping: US$ 7.91
From United Kingdom to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Patel Ravi B., R Badmanaban, Dave J. B.
Published by LAP Lambert Academic Publishing 2013-07-24 (2013)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New paperback Quantity Available: > 20
Seller:
Blackwell's
(Oxford, OX, United Kingdom)
Rating
[?]

Book Description LAP Lambert Academic Publishing 2013-07-24, 2013. paperback. Book Condition: New. Bookseller Inventory # 9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 51.61
Convert Currency

Add to Basket

Shipping: US$ 7.91
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

Patel, Ravi B. / Badmanaban, R.
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Quantity Available: 1
Seller:
Rating
[?]

Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Analytical Method Development & Validation | A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 µg/mL and 10-60 µg/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. | Format: Paperback | Language/Sprache: english | 84 pp. Bookseller Inventory # K9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 59.99
Convert Currency

Add to Basket

Shipping: US$ 3.51
From Germany to U.S.A.
Destination, Rates & Speeds

3.

Patel Ravi B
Published by LAP Lambert Academic Publishing (2013)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description LAP Lambert Academic Publishing, 2013. PAP. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IQ-9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 61.28
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

4.

Patel Ravi B.
Published by LAP Lambert Academic Publishing (2016)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description LAP Lambert Academic Publishing, 2016. Paperback. Book Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Bookseller Inventory # ria9783659425288_lsuk

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 61.57
Convert Currency

Add to Basket

Shipping: US$ 5.10
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

Patel Ravi B
Published by LAP Lambert Academic Publishing (2013)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Quantity Available: > 20
Print on Demand
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description LAP Lambert Academic Publishing, 2013. PAP. Book Condition: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # LQ-9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 56.10
Convert Currency

Add to Basket

Shipping: US$ 11.88
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

Ravi B. Patel
Published by LAP Lambert Academic Publishing
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Taschenbuch Quantity Available: 1
Seller:
Rheinberg-Buch
(Bergisch Gladbach, Germany)
Rating
[?]

Book Description LAP Lambert Academic Publishing. Taschenbuch. Book Condition: Neu. Neuware - A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 µg/mL and 10-60 µg/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. 84 pp. Englisch. Bookseller Inventory # 9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 60.41
Convert Currency

Add to Basket

Shipping: US$ 20.13
From Germany to U.S.A.
Destination, Rates & Speeds

7.

Ravi B. Patel
Published by LAP Lambert Academic Publishing
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Taschenbuch Quantity Available: 1
Seller:
Agrios-Buch
(Bergisch Gladbach, Germany)
Rating
[?]

Book Description LAP Lambert Academic Publishing. Taschenbuch. Book Condition: Neu. Neuware - A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 µg/mL and 10-60 µg/mL with R2 of 0.9998 and 0.9989 for CEF & TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF & TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. 84 pp. Englisch. Bookseller Inventory # 9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 60.41
Convert Currency

Add to Basket

Shipping: US$ 20.13
From Germany to U.S.A.
Destination, Rates & Speeds

8.

Patel, Ravi B.; Badmanaban, R.; Dave, J. B.
Published by LAP LAMBERT Academic Publishing (2013)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Paperback Quantity Available: 10
Print on Demand
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description LAP LAMBERT Academic Publishing, 2013. Paperback. Book Condition: New. This item is printed on demand. Bookseller Inventory # INGM9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 79.01
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

9.

R. Badmanaban
Published by LAP Lambert Academic Publishing
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Paperback Quantity Available: > 20
Seller:
BuySomeBooks
(Las Vegas, NV, U.S.A.)
Rating
[?]

Book Description LAP Lambert Academic Publishing. Paperback. Book Condition: New. Paperback. 84 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 gmL and 10-60 gmL with R2 of 0. 9998 and 0. 9989 for CEF and TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ngband for CEF and 2000-12000 ngband for TAZO with R2 of 0. 9993 and 0. 9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF and TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 94.26
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

10.

Patel Ravi B, Badmanaban R, Dave J B
Published by LAP Lambert Academic Publishing, United States (2013)
ISBN 10: 3659425281 ISBN 13: 9783659425288
New Paperback Quantity Available: 1
Seller:
The Book Depository EURO
(London, United Kingdom)
Rating
[?]

Book Description LAP Lambert Academic Publishing, United States, 2013. Paperback. Book Condition: New. Language: English . Brand New Book. A fixed dose combination of Ceftazidime(CEF) and Tazobactam(TAZO) is used as powder form of injection for the treatment of resistant lower respiratory tract and other infections. Stability indicating RP-HPLC and HPTLC methods were developed and validated for estimation of CEF and TAZO in an injection. RP-HPLC method was linear in the concentration range of 80-480 ug/mL and 10-60 ug/mL with R2 of 0.9998 and 0.9989 for CEF TAZO respectively. Both the drugs were susceptible to acidic, alkaline and oxidative hydrolysis conditions. HPTLC method was linear in the concentration range of 1000-6000 ng/band for CEF and 2000-12000 ng/band for TAZO with R2 of 0.9993 and 0.9991 for respective drugs. The present work describes simple, economical and non interfering methods for estimation of CEF TAZO. The methods were validated and found to be sensitive, accurate and precise. Percentage recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the proposed methods can be used for routine analysis. The method effectively separated the drugs from their degradation products so it can be used as a stability-indicating assay method. Bookseller Inventory # KNV9783659425288

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 90.63
Convert Currency

Add to Basket

Shipping: US$ 3.96
From United Kingdom to U.S.A.
Destination, Rates & Speeds