Neurotransmitter Receptor Ligands

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9783659529825: Neurotransmitter Receptor Ligands

A broad range of severe pathologies such as pain, anxiety, neurodegeneration,hypertension, asthma, as well as some gastrointestinal diseases, are due to receptordysfunction. Some of these pathologies have a tremendous social impact as they involve large population segments, in particular aged people. The systems more frequently involved in these pathologies are adenosinic, adrenergic, aminoacidergic, cholinergic(muscarinic and nicotinic), dopaminergic, imidazoline, triptaminergic, and sigma receptors as well as Wnt pathway. The goals of the research reported in this book intended (i) to obtain more information about structure, functions and dysfunctions of neurotransmitter receptors, (ii) to individuate novel leads to develop useful drugs in the treatment of neuroreceptor dysfunctions. Therefore imidazoline, 1, 4-dioxane and spiropiperidine nuclei were utilized for designing novel 2-adrenergic, imidazoline, dopaminergic, muscarinic, 5-HT1A-serotoninergic and sigma ligands (VII), respectively. Finally, new azaindole analogues have been synthesized as RHO kinase inhibitors (I, II).

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Completed Masters degree in Chemistry in June 2000, worked in Glenmark Research Center in Mumbai, India for 7 yrs. Completed PhD in Medicinal Chemistry at Camerino University Italy in 2010 and worked as Post Doctoral fellow till 2011 in Italy. Returned to India in 2011 and worked as Scientist in a Pharma company. Presently working as a lecturer.

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | A broad range of severe pathologies such as pain, anxiety, neurodegeneration,hypertension, asthma, as well as some gastrointestinal diseases, are due to receptordysfunction. Some of these pathologies have a tremendous social impact as they involve large population segments, in particular aged people. The systems more frequently involved in these pathologies are adenosinic, adrenergic, aminoacidergic, cholinergic(muscarinic and nicotinic), dopaminergic, imidazoline, triptaminergic, and sigma receptors as well as Wnt pathway. The goals of the research reported in this book intended (i) to obtain more information about structure, functions and dysfunctions of neurotransmitter receptors, (ii) to individuate novel leads to develop useful drugs in the treatment of neuroreceptor dysfunctions. Therefore imidazoline, 1, 4-dioxane and spiropiperidine nuclei were utilized for designing novel 2-adrenergic, imidazoline, dopaminergic, muscarinic, 5-HT1A-serotoninergic and sigma ligands (VII), respectively. Finally, new azaindole analogues have been synthesized as RHO kinase inhibitors (I, II). | Format: Paperback | Language/Sprache: english | 100 pp. Bookseller Inventory # K9783659529825

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Book Description LAP Lambert Academic Publishing Mai 2014, 2014. Taschenbuch. Book Condition: Neu. Neuware - A broad range of severe pathologies such as pain, anxiety, neurodegeneration,hypertension, asthma, as well as some gastrointestinal diseases, are due to receptordysfunction. Some of these pathologies have a tremendous social impact as they involve large population segments, in particular aged people. The systems more frequently involved in these pathologies are adenosinic, adrenergic, aminoacidergic, cholinergic(muscarinic and nicotinic), dopaminergic, imidazoline, triptaminergic, and sigma receptors as well as Wnt pathway. The goals of the research reported in this book intended (i) to obtain more information about structure, functions and dysfunctions of neurotransmitter receptors, (ii) to individuate novel leads to develop useful drugs in the treatment of neuroreceptor dysfunctions. Therefore imidazoline, 1, 4-dioxane and spiropiperidine nuclei were utilized for designing novel 2-adrenergic, imidazoline, dopaminergic, muscarinic, 5-HT1A-serotoninergic and sigma ligands (VII), respectively. Finally, new azaindole analogues have been synthesized as RHO kinase inhibitors (I, II). 100 pp. Englisch. Bookseller Inventory # 9783659529825

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Book Description LAP Lambert Academic Publishing Mai 2014, 2014. Taschenbuch. Book Condition: Neu. Neuware - A broad range of severe pathologies such as pain, anxiety, neurodegeneration,hypertension, asthma, as well as some gastrointestinal diseases, are due to receptordysfunction. Some of these pathologies have a tremendous social impact as they involve large population segments, in particular aged people. The systems more frequently involved in these pathologies are adenosinic, adrenergic, aminoacidergic, cholinergic(muscarinic and nicotinic), dopaminergic, imidazoline, triptaminergic, and sigma receptors as well as Wnt pathway. The goals of the research reported in this book intended (i) to obtain more information about structure, functions and dysfunctions of neurotransmitter receptors, (ii) to individuate novel leads to develop useful drugs in the treatment of neuroreceptor dysfunctions. Therefore imidazoline, 1, 4-dioxane and spiropiperidine nuclei were utilized for designing novel 2-adrenergic, imidazoline, dopaminergic, muscarinic, 5-HT1A-serotoninergic and sigma ligands (VII), respectively. Finally, new azaindole analogues have been synthesized as RHO kinase inhibitors (I, II). 100 pp. Englisch. Bookseller Inventory # 9783659529825

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