Receptor polymorphisms and non-classical bacterial immune stimuli: Variants of the human TLR4 and of the bacterial surface molecules LPS and LTA - their ... roles in innate immunity

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9783838106540: Receptor polymorphisms and non-classical bacterial immune stimuli: Variants of the human TLR4 and of the bacterial surface molecules LPS and LTA - their ... roles in innate immunity

The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence.

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Oliver Dehus, Dr. rer. nat.: Study of Biology at the University of Konstanz, Germany, with focus on molecular immunology. Dissertation at the Chair of Biochemical Pharmacology in 2008.

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Oliver Dehus
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Book Description Book Condition: New. Publisher/Verlag: Südwestdeutscher Verlag für Hochschulschriften | Variants of the human TLR4 and of the bacterial surface molecules LPS and LTA - their specific roles in innate immunity | The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence. | Format: Paperback | 100 pp. Bookseller Inventory # K9783838106540

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Book Description Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Book Condition: Neu. Neuware - The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence. 100 pp. Deutsch. Bookseller Inventory # 9783838106540

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Book Description Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Book Condition: Neu. Neuware - The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence. 100 pp. Deutsch. Bookseller Inventory # 9783838106540

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Book Description Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Aug 2015, 2015. Taschenbuch. Book Condition: Neu. This item is printed on demand - Print on Demand Neuware - The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence. 100 pp. Deutsch. Bookseller Inventory # 9783838106540

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Book Description Sudwestdeutscher Verlag Fur Hochschulschriften, Germany, 2012. Paperback. Book Condition: New. Language: English . Brand New Book. The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn s Disease. The focus of the second part is the functional analysis of non-classical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipo-polysaccharide and lipo-teichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for host-pathogen interaction and immune defence. Bookseller Inventory # KNV9783838106540

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