PREPARATION OF SOME DERIVATIVES OF OPEN-LACTAM FORM OF PRAZIQUANTEL

 
9783843354561: PREPARATION OF SOME DERIVATIVES OF OPEN-LACTAM FORM OF PRAZIQUANTEL

The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100%, in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated,No praziquantel or its hydroxy metabolites were detected.

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | PREPARATION AND INVESTIGATION OF ANTHELMINTIC ACTIVITIES OF SOME DERIVATIVES OF THE OPEN-LACTAM FORM OF PRAZIQUANTEL | The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100%, in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated,No praziquantel or its hydroxy metabolites were detected. | Format: Paperback | Language/Sprache: english | 256 pp. Bookseller Inventory # K9783843354561

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Book Description LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100%, in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated,No praziquantel or its hydroxy metabolites were detected. 256 pp. Englisch. Bookseller Inventory # 9783843354561

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Book Description LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100%, in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated,No praziquantel or its hydroxy metabolites were detected. 256 pp. Englisch. Bookseller Inventory # 9783843354561

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Book Description LAP Lambert Acad. Publ. Okt 2010, 2010. Taschenbuch. Book Condition: Neu. This item is printed on demand - Print on Demand Neuware - The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100%, in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated,No praziquantel or its hydroxy metabolites were detected. 256 pp. Englisch. Bookseller Inventory # 9783843354561

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Book Description LAP Lambert Academic Publishing, Germany, 2010. Paperback. Book Condition: New. Language: English . Brand New Book. The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH/-COOH) groups.The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100 , in a dose of 20 mg/kg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated, No praziquantel or its hydroxy metabolites were detected. Bookseller Inventory # KNV9783843354561

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Book Description LAP LAMBERT Academic Publishing. Paperback. Book Condition: New. 256 pages. Dimensions: 8.7in. x 5.9in. x 0.6in.The lactam ring of the parent praziquantel was opened through hot alkaline hydrolysis. The resultant open lactam form of praziquantel (OLF- PZQ) has been subjected to various functionalization and interconversions of the amino and carboxylic acid (-NH-COOH) groups. The methods of synthesis, and the mechanism for some selected reactions are given and discussed. Representatives of the different classes of compounds were selected and tested for their antischistosomal activity against S. mansoni in albino mice. The results indicated that these compounds were more effective on worms reduction than praziquantel. It can be seen that, compound (VIII) has six folds the antischistosomal activity of praziquantel. All the compounds have been found to possess anticestodal activity when tested against R- tetragona in Bovans type chicks, ranged from 14 to 100, in a dose of 20 mgkg body weight given twice in 72 hours. No clear toxicity was observed for all the tested compounds. In vivo biocyclization of some compounds has been investigated, No praziquantel or its hydroxy metabolites were detected. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783843354561

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