Loss of Heterozygosity of PTEN Gene in Cervical Carcinoma: Mutations in the PTEN tumor suppressor gene in cervical carcinomas

 
9783843367479: Loss of Heterozygosity of PTEN Gene in Cervical Carcinoma: Mutations in the PTEN tumor suppressor gene in cervical carcinomas
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Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 31 out of 133(23%) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8% to 13%. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region.

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Kumar Lalit (author), Ram Chhotu (author), Kumar Vinay (author)
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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Mutations in the PTEN tumor suppressor gene in cervical carcinomas | Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 31 out of 133(23%) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8% to 13%. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. | Format: Paperback | Language/Sprache: english | 72 pp. Seller Inventory # K9783843367479

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Book Description LAP Lambert Academic Publishing Dez 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 31 out of 133(23%) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8% to 13%. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. 72 pp. Englisch. Seller Inventory # 9783843367479

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Lalit Kumar
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Book Description LAP Lambert Academic Publishing Dez 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 31 out of 133(23%) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8% to 13%. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. 72 pp. Englisch. Seller Inventory # 9783843367479

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Book Description LAP Lambert Academic Publishing. Paperback. Condition: New. 72 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8 denaturing polyacrylamide gel. Overall, 31 out of 133(23) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8 to 13. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Seller Inventory # 9783843367479

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KUMAR LALIT, Ram Chhotu, Kumar Vinay
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Book Description LAP Lambert Academic Publishing, United States, 2012. Paperback. Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8 denaturing polyacrylamide gel. Overall, 31 out of 133(23 ) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8 to 13 . Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. Seller Inventory # AAV9783843367479

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