Loss of Heterozygosity of PTEN Gene in Cervical Carcinoma: Mutations in the PTEN tumor suppressor gene in cervical carcinomas

 
9783843367479: Loss of Heterozygosity of PTEN Gene in Cervical Carcinoma: Mutations in the PTEN tumor suppressor gene in cervical carcinomas

Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8% denaturing polyacrylamide gel. Overall, 31 out of 133(23%) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8% to 13%. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region.

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Scientist at BUREAU OF INDIAN STANDARDS NEW DELHI.

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Book Description LAP Lambert Academic Publishing, United States, 2012. Paperback. Book Condition: New. 220 x 150 mm. Language: English . Brand New Book ***** Print on Demand *****.Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8 denaturing polyacrylamide gel. Overall, 31 out of 133(23 ) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8 to 13 . Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. Bookseller Inventory # AAV9783843367479

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Book Description LAP LAMBERT Academic Publishing. Paperback. Book Condition: New. Paperback. 72 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers and one marker in flanking region and further electrophoresed on 8 denaturing polyacrylamide gel. Overall, 31 out of 133(23) informative cases showed loss of heterozygosity in at least one locus in the region examined. The percentage of loss of heterozygosity for these markers ranged from 8 to 13. Loss of heterozygosity was more frequently detected in intragenic region than in flanking region. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783843367479

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