THE UPTAKE AND DEPLETION OF TOCOPHEROLS: THE UPTAKE AND DEPLETION OF TOCOPHEROLS IN RAW 264.7 MACROPHAGES

 
9783843374125: THE UPTAKE AND DEPLETION OF TOCOPHEROLS: THE UPTAKE AND DEPLETION OF TOCOPHEROLS IN RAW 264.7 MACROPHAGES

As an important chain-breaking antioxidant, the role of Vitamin E has attracted attentions from all over the world. Alpha-Tocopherol and gamma-tocopherol are two of the eight different forms of vitamin E. The dietary intake of gamma-tocopherol is generally higher than that of alpha-tocopherol. However, the levels of alpha-tocopherol in human blood have consistently been shown to be higher than those of gamma-tocopherol. This could be due, in part, to a differential cellular uptake of the two tocopherol forms. We sought to resolve this question by studying the uptake and depletion of both alpha-tocopherol and gamma-tocopherol in RAW 264.7 macrophages. The results indicate that a faster uptake and depletion of gamma-tocopherol compared with alpha-tocopherol. The presence of gamma-tocopherol can promote the uptake of alpha-tocopherol by macrophages. The metabolism of alpha-tocopherol was faster than gamma-tocopherol. These results implied the existence of a hypothetical transport protein, which can preferentially select gamma-tocopherol over alpha-tocopherol. The affinity of this transport protein for alpha-tocopherol could be increased by the presence of gamma-tocopherol.

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Ph.D., specialist at protein chemistry. She earned a M.S. in Chemistry from East Tennessee State University at Johnson City, TN, USA in 2000. Under the direction of Dr. William L. Stone, her major research in ETSU was focused on studying the metabolism of tocopherols in Raw 264.7 macrophages, which were described in detail in this book.

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Gao, Rong
Published by LAP Lambert Academic Publishing (2010)
ISBN 10: 3843374120 ISBN 13: 9783843374125
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