EFFECT OF STRAIN AND STIFFNESS ON MATRIX REMODELLING GENES: 3D COLLAGEN CONSTRUCTS IN TISSUE ENGINEERING

 
9783843379564: EFFECT OF STRAIN AND STIFFNESS ON MATRIX REMODELLING GENES: 3D COLLAGEN CONSTRUCTS IN TISSUE ENGINEERING

The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired.

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Education: BEng-Electrical&Electronic Eng,MMU,UK MSc-Engineering&Physical Sciences in Medicine,Imperial College,UK PhD-Tissue Engineering,UCL,UK Career: 2005 Research Fellow,UCL,Inst of Orthopaedics 2006 Research Fellow,UT Southwestern medical center,Dept Ophthalmology 2008 Senior Research Associate,Schepens Eye Research Inst, Harvard Medical Sch

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | 3D COLLAGEN CONSTRUCTS IN TISSUE ENGINEERING | The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. | Format: Paperback | Language/Sprache: english | 192 pp. Bookseller Inventory # K9783843379564

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Book Description LAP Lambert Acad. Publ. Dez 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. 192 pp. Englisch. Bookseller Inventory # 9783843379564

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Book Description LAP Lambert Acad. Publ. Dez 2010, 2010. Taschenbuch. Book Condition: Neu. Neuware - The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. 192 pp. Englisch. Bookseller Inventory # 9783843379564

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Book Description LAP Lambert Acad. Publ. Dez 2010, 2010. Taschenbuch. Book Condition: Neu. This item is printed on demand - Print on Demand Neuware - The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. 192 pp. Englisch. Bookseller Inventory # 9783843379564

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Book Description LAP Lambert Academic Publishing. Paperback. Book Condition: New. Paperback. 192 pages. Dimensions: 8.7in. x 5.9in. x 0.4in.The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783843379564

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Book Description LAP Lambert Academic Publishing, Germany, 2010. Paperback. Book Condition: New. Language: English . Brand New Book. The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblast-seeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong co-relation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired. Bookseller Inventory # KNV9783843379564

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