The Role of Activating Residual Neurons in Recovery of Vision After Partial Optic Nerve Damage: In Vivo Observations in Rats (Berichte aus der Medizin)

 
9783844001068: The Role of Activating Residual Neurons in Recovery of Vision After Partial Optic Nerve Damage: In Vivo Observations in Rats (Berichte aus der Medizin)
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Sylvia Prilloff
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Prilloff, Sylvia
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Book Description Imprint unknown, 2011. Paperback. Condition: Brand New. 87 pages. 8.31x5.87x0.47 inches. In Stock. Seller Inventory # __3844001069

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Sylvia Prilloff
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Book Description Shaker Verlag Mai 2011, 2011. Buch. Condition: Neu. Neuware - Wie lässt sich blitzschnell eine Lieblingszahl oder ein Geburtsdatum errechnen Welchen Griff muss man kennen, um in Windeseile gefesselte Hände zu befreien Für alle, die gern 'um die Ecke denken', bietet dieses unterhaltsame Buch mehr als 50 faszinierende Rätsel, Spiele und Tricks mit Fäden, Flächen, Münzen, Knoten, Ringen, Gläsern oder Buntstiften. Alle Knobeleien, in sieben Kapiteln ausführlich vorgestellt, erfordern Geduld, Geschick und viel Fantasie. Die Kniffeleien sind so gewählt, dass man sie allein, im Familienkreis oder in der Gruppe austüfteln kann. Besonders viel Spaß macht es natürlich, anderen ein schwieriges Problem vorzuführen und seine Zuschauer mit der Lösung zu verblüffen. 90 pp. Englisch. Seller Inventory # 9783844001068

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Sylvia Prilloff
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Book Description Shaker Verlag Mai 2011, 2011. Taschenbuch. Condition: Neu. Neuware - Traurnatic brain injury is one of the main causes of functional loss in the central nervous system after injury. These functional deficits are often not pennanent hut can be partially regained from the brain often surprisingly and partly spontaneously in the first few weeks after the lesion. A small nurnber of retinal ganglion cells (10-20 %) are sufficient to spontaneously recover lost functions. It is now necessary to acquire more knowledge about the role of activating residual neurons in the recovery of vision after partial optic nerve darnage as this is ofhigh clinical relevance. To learn more about this issue, a defined ONC in adult rats was used to analyse the functional recovery by using behaviour and cell biological methods. First, the in vivo conföcal neuroimaging (ICON) was used for the non-invasive visualization of individual retina! ganglion cells (RGCs), and second an automated test system to study the psychophysics of rat vision (VIST). By applying these two procedures significant new insights have been gained regarding neurobiological mechanisms of functional recovery after partial injury ofthe visuaI system: - It is possible to use two different fluorescent markers under in vivo conditions in order to observe retrograde axonal transport in RGCs in living rats. With this design an effective protocol is in place to observe the temporal pattern of recovery of retrograde axonal transport in injured RGCs. - By ONC the axons ofthe RGCs are darnaged which results in a temporary loss ofaxonal transport. The results from the double-Iabelling studies described here show that there is an intrinsic repair of darnaged axons. The axonal transport in the injured optic nerve recovered within 2-3 weeks and consequently the visuaI function, too. As expected, axotomy did not allow such recovery. - The in vivo imaging of calcium dynamics in individual RGCs is an important indication of the function or injury of these cells. Surviving RGCs show a delayed moderate ('compensatory') calcium activation, which is significantly different from cell deathassociated massive calcium influx, which occurs immediately after the injury. - The repeated stimulation of the visuaI system following ONC has a positive effect on the recovery of vision. It could be observed, that 'visuaI enrichment' produced a faster recovery of vision in rats compared to rats kept under normal dark/light conditions or rats held in total darkness. These results show that activating residual neurons is a very important mechanism in recovery of vision. Through these new findings it is possible to understand the role of residual neurons much better and it allows new approaches for the development of potential therapies. 90 pp. Englisch. Seller Inventory # 9783844001068

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Sylvia Prilloff
Published by Shaker Verlag Mai 2011 (2011)
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Book Description Shaker Verlag Mai 2011, 2011. Taschenbuch. Condition: Neu. Neuware - Traurnatic brain injury is one of the main causes of functional loss in the central nervous system after injury. These functional deficits are often not pennanent hut can be partially regained from the brain often surprisingly and partly spontaneously in the first few weeks after the lesion. A small nurnber of retinal ganglion cells (10-20 %) are sufficient to spontaneously recover lost functions. It is now necessary to acquire more knowledge about the role of activating residual neurons in the recovery of vision after partial optic nerve darnage as this is ofhigh clinical relevance. To learn more about this issue, a defined ONC in adult rats was used to analyse the functional recovery by using behaviour and cell biological methods. First, the in vivo conföcal neuroimaging (ICON) was used for the non-invasive visualization of individual retina! ganglion cells (RGCs), and second an automated test system to study the psychophysics of rat vision (VIST). By applying these two procedures significant new insights have been gained regarding neurobiological mechanisms of functional recovery after partial injury ofthe visuaI system: - It is possible to use two different fluorescent markers under in vivo conditions in order to observe retrograde axonal transport in RGCs in living rats. With this design an effective protocol is in place to observe the temporal pattern of recovery of retrograde axonal transport in injured RGCs. - By ONC the axons ofthe RGCs are darnaged which results in a temporary loss ofaxonal transport. The results from the double-Iabelling studies described here show that there is an intrinsic repair of darnaged axons. The axonal transport in the injured optic nerve recovered within 2-3 weeks and consequently the visuaI function, too. As expected, axotomy did not allow such recovery. - The in vivo imaging of calcium dynamics in individual RGCs is an important indication of the function or injury of these cells. Surviving RGCs show a delayed moderate ('compensatory') calcium activation, which is significantly different from cell deathassociated massive calcium influx, which occurs immediately after the injury. - The repeated stimulation of the visuaI system following ONC has a positive effect on the recovery of vision. It could be observed, that 'visuaI enrichment' produced a faster recovery of vision in rats compared to rats kept under normal dark/light conditions or rats held in total darkness. These results show that activating residual neurons is a very important mechanism in recovery of vision. Through these new findings it is possible to understand the role of residual neurons much better and it allows new approaches for the development of potential therapies. 90 pp. Englisch. Seller Inventory # 9783844001068

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Sylvia Prilloff
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Sylvia Prilloff
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Sylvia Prilloff
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Book Description Shaker Verlag Mai 2011, 2011. Taschenbuch. Condition: Neu. Neuware - Traurnatic brain injury is one of the main causes of functional loss in the central nervous system after injury. These functional deficits are often not pennanent hut can be partially regained from the brain often surprisingly and partly spontaneously in the first few weeks after the lesion. A small nurnber of retinal ganglion cells (10-20 %) are sufficient to spontaneously recover lost functions. It is now necessary to acquire more knowledge about the role of activating residual neurons in the recovery of vision after partial optic nerve darnage as this is ofhigh clinical relevance. To learn more about this issue, a defined ONC in adult rats was used to analyse the functional recovery by using behaviour and cell biological methods. First, the in vivo conföcal neuroimaging (ICON) was used for the non-invasive visualization of individual retina! ganglion cells (RGCs), and second an automated test system to study the psychophysics of rat vision (VIST). By applying these two procedures significant new insights have been gained regarding neurobiological mechanisms of functional recovery after partial injury ofthe visuaI system: - It is possible to use two different fluorescent markers under in vivo conditions in order to observe retrograde axonal transport in RGCs in living rats. With this design an effective protocol is in place to observe the temporal pattern of recovery of retrograde axonal transport in injured RGCs. - By ONC the axons ofthe RGCs are darnaged which results in a temporary loss ofaxonal transport. The results from the double-Iabelling studies described here show that there is an intrinsic repair of darnaged axons. The axonal transport in the injured optic nerve recovered within 2-3 weeks and consequently the visuaI function, too. As expected, axotomy did not allow such recovery. - The in vivo imaging of calcium dynamics in individual RGCs is an important indication of the function or injury of these cells. Surviving RGCs show a delayed moderate ('compensatory') calcium activation, which is significantly different from cell deathassociated massive calcium influx, which occurs immediately after the injury. - The repeated stimulation of the visuaI system following ONC has a positive effect on the recovery of vision. It could be observed, that 'visuaI enrichment' produced a faster recovery of vision in rats compared to rats kept under normal dark/light conditions or rats held in total darkness. These results show that activating residual neurons is a very important mechanism in recovery of vision. Through these new findings it is possible to understand the role of residual neurons much better and it allows new approaches for the development of potential therapies. 90 pp. Englisch. Seller Inventory # 9783844001068

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