Drosophila melanogaster an model system for toxicity studies: Biochemical studies on anti-oxidative enzyme activity in Drosophila melanogaster against pesticide exposure

 
9783845411477: Drosophila melanogaster an model system for toxicity studies: Biochemical studies on anti-oxidative enzyme activity in Drosophila melanogaster against pesticide exposure
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The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes

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Deepak Balaji TG holds double masters graduate (ME Biotechnology from BITS Pilani, MS Molecular Engineering from Singapore-MIT Alliance) and a PhD in biomedical sciences from KU Leuven, Belgium.

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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Biochemical studies on anti-oxidative enzyme activity in Drosophila melanogaster against pesticide exposure | The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes | Format: Paperback | Language/Sprache: english | 68 pp. Seller Inventory # K9783845411477

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Book Description LAP Lambert Acad. Publ. Jul 2011, 2011. Taschenbuch. Condition: Neu. Neuware - The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes 68 pp. Englisch. Seller Inventory # 9783845411477

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Book Description LAP Lambert Acad. Publ. Jul 2011, 2011. Taschenbuch. Condition: Neu. Neuware - The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes 68 pp. Englisch. Seller Inventory # 9783845411477

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Book Description LAP Lambert Academic Publishing, Germany, 2011. Paperback. Condition: New. Language: English . Brand New Book. The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes. Seller Inventory # KNV9783845411477

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Book Description LAP Lambert Acad. Publ. Jul 2011, 2011. Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Neuware - The purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at the highest concentration of Dichlorvos indicates severity of the pesticide action on the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity indicates oxidative stress caused by the organophosphate pesticides in the exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes 68 pp. Englisch. Seller Inventory # 9783845411477

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