Histone Deacetylase Inhibitors: In Treatment of Leukemia

 
9783845417752: Histone Deacetylase Inhibitors: In Treatment of Leukemia

Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia.

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About the Author:

Avineesh Singh, is research scholar at GGU, Bilaspur C.G. India. He isawarded as SRF by the CSIR, Govt. of India. He has published 4 articles in SCI journals. Dr. Harish Rajak is Assistant Professor of Pharmaceutical Medicinal Chemistry at Institute of Pharmaceutical Sciences.He has published 45 peer-reviewed articles in SCI journals.

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Book Description Book Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia. | Format: Paperback | Language/Sprache: english | 80 pp. Bookseller Inventory # K9783845417752

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Book Description LAP Lambert Academic Publishing Nov 2013, 2013. Taschenbuch. Book Condition: Neu. Neuware - Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia. 80 pp. Englisch. Bookseller Inventory # 9783845417752

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Book Description LAP Lambert Academic Publishing Nov 2013, 2013. Taschenbuch. Book Condition: Neu. Neuware - Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia. 80 pp. Englisch. Bookseller Inventory # 9783845417752

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Book Description LAP LAMBERT Academic Publishing. Paperback. Book Condition: New. Paperback. 80 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Bookseller Inventory # 9783845417752

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Book Description LAP Lambert Academic Publishing, United States, 2013. Paperback. Book Condition: New. Language: English . Brand New Book ***** Print on Demand *****.Leukemia is a type of cancer caused by the acquisition of gene mutations that bestow deregulated proliferation, impaired differentiation. There is continuing interest to recognize the signaling pathways and genes that play a crucial function in carcinogenesis and the development of resistance to antitumor drugs. The histone deacetylases (HDACs) has been found to interact with many partners through complex molecular mechanism leading to the regulation of gene expression, they have obtained the interest of a large number of researchers. Several HDAC inhibitors (HDACis) have been confirmed to proficiently protect against the growth of tumor cells in vitro as well as in vivo. Thus it is expected that some of the HDACi could be potential effective anti-leukemic drugs. In this book, we have summarized the current status of different classes of HDACs, epigenesis, apoptosis and role of HDAC inhibitors in therapeutics for the treatment of different types of leukemia. Bookseller Inventory # AAV9783845417752

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