Polymeric Dispersions of Highly Water Soluble Drug: Tiwari et al. solid dispersions of highly water soluble drug

 
9783848444113: Polymeric Dispersions of Highly Water Soluble Drug: Tiwari et al. solid dispersions of highly water soluble drug
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Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2)< double distilled water< phosphate buffer (pH 7.4). The results of adsorption studies indicated that Eudragit RLPO had greater capacity to adsorb drug as compared to Eudragit RS100 in phosphate buffer (pH 7.4). The content homogeneity of PHC in granule was very high, as all the components in solid dispersions were dispersed and mixed on the molecule level. The dissolution of PHC, which is highly soluble in water, was markedly improved in the solid dispersions.

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Dr. Gaurav Tiwari (Assistant Professor) in the institute of Pharmacy, PSIT, Kanpur. He did his M.Pharm from Uttar Pradesh Technical University, Uttar Pradesh and Ph.D from Jaipur National University, Jaipur. He has five years of teaching experience and three year research experience, having more than 45 national and international publications.

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Book Description Condition: New. Publisher/Verlag: LAP Lambert Academic Publishing | Tiwari et al. solid dispersions of highly water soluble drug | Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2) double distilled water phosphate buffer (pH 7.4). The results of adsorption studies indicated that Eudragit RLPO had greater capacity to adsorb drug as compared to Eudragit RS100 in phosphate buffer (pH 7.4). The content homogeneity of PHC in granule was very high, as all the components in solid dispersions were dispersed and mixed on the molecule level. The dissolution of PHC, which is highly soluble in water, was markedly improved in the solid dispersions. | Format: Paperback | Language/Sprache: english | 120 pp. Seller Inventory # K9783848444113

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Book Description LAP Lambert Academic Publishing Apr 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2) double distilled water phosphate buffer (pH 7.4). The results of adsorption studies indicated that Eudragit RLPO had greater capacity to adsorb drug as compared to Eudragit RS100 in phosphate buffer (pH 7.4). The content homogeneity of PHC in granule was very high, as all the components in solid dispersions were dispersed and mixed on the molecule level. The dissolution of PHC, which is highly soluble in water, was markedly improved in the solid dispersions. 120 pp. Englisch. Seller Inventory # 9783848444113

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Book Description LAP Lambert Academic Publishing Apr 2012, 2012. Taschenbuch. Condition: Neu. Neuware - Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2) double distilled water phosphate buffer (pH 7.4). The results of adsorption studies indicated that Eudragit RLPO had greater capacity to adsorb drug as compared to Eudragit RS100 in phosphate buffer (pH 7.4). The content homogeneity of PHC in granule was very high, as all the components in solid dispersions were dispersed and mixed on the molecule level. The dissolution of PHC, which is highly soluble in water, was markedly improved in the solid dispersions. 120 pp. Englisch. Seller Inventory # 9783848444113

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Book Description LAP Lambert Academic Publishing. Paperback. Condition: New. 120 pages. Dimensions: 8.7in. x 5.9in. x 0.3in.Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0. 1 N HCl (pH 1. 2) double distilled water phosphate buffer (pH 7. 4). The results of adsorption studies indicated that Eudragit RLPO had greater capacity to adsorb drug as compared to Eudragit RS100 in phosphate buffer (pH 7. 4). The content homogeneity of PHC in granule was very high, as all the components in solid dispersions were dispersed and mixed on the molecule level. The dissolution of PHC, which is highly soluble in water, was markedly improved in the solid dispersions. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Paperback. Seller Inventory # 9783848444113

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Book Description LAP Lambert Academic Publishing, Germany, 2012. Paperback. Condition: New. Aufl.. Language: English . Brand New Book ***** Print on Demand *****.Extended release of solid dispersion of water soluble PHC was successively prepared by coevaporation with Eudragit RLPO in 1: 5 ratios. The sustainment of drug release was effected by drug-polymer ratio and method of preparation. The analysis by spectral techniques (FT-IR, FT-NMR) suggested possibility of hydrogen bonding. The results of DSC, XRD and SEM studies revealed the reduction in crystallinity of pure drug in solid dispersions as compared to their physical mixtures. The results of solubility studies were in accordance with the in vitro release profile and the order of sustainment of drug release was found in rank order of 0.1 N HCl (pH 1.2). Seller Inventory # AAV9783848444113

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