Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium). 104 pp. Englisch. Seller Inventory # 9786202557078

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Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives: Aryl Propionic Acid Derivatives

Kumar, Punet; Mishra, Arun K; KUMAR, ARVIND

Published by LAP LAMBERT Academic Publishing, 2020

ISBN 10: 6202557079 ISBN 13: 9786202557078

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Synthesis And Evaluation Of Some Aryl Propionic Acid Derivatives : Aryl Propionic Acid Derivatives

Punet Kumar

Published by LAP LAMBERT Academic Publishing, 2020

ISBN 10: 6202557079 ISBN 13: 9786202557078

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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The book emphasizes the methods that chemists use to conduct their research and design the new series of 3,3-diphenyl propionic acid derivatives were synthesized The key intermediate 3,3-diphenylpropionyl chloride was synthesized by the reaction of 3,3-diphenyl propionic acid and thionyl chloride. The intermediate was further subjected to reaction with various aromatic secondary amines in the presence of NaOH in acetone. After synthesis of compounds, the synthesized compounds were characterized by their IR, 1HNMR, Mass spectral data, and elemental analysis. These derivatives were screened for their analgesic activity (Hot plate and tail flick method) and anti-inflammatory activity (Carrageen induced rat paw edema method) by using Diclofenac sodium and Indomethacin as standard drugs, respectively. The compounds AK-5 and AK-3 exhibited significantly potent anti-inflammatory and analgesic activity (two to three times) when a comparison was made with the control group. The response of promising compound (AK-5) for analgesic and anti-inflammatory action was highest among all the test compounds and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium). Seller Inventory # 9786202557078

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