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In Samhitas of Caraka, Susruta and Vagbhata, the subject matter of Dravyaguna is found in scattered form. Later on it was very much felt to arrange the information regarding drugs of these samhitas together in the form of Nighantus so that knowledge of drugs mentioned in these Sarnhitas may become easy to approach. That is why Nighantus on Sarnhitas viz.- Caraka, Susruta and ~tafiga Hrdaya were composed which have description of drugs of respective treatises. Today, Sausruta Nighantu and ~tafiga Nighantu are available and published however, there is no any definite information regarding Nighantu based on drugs of Caraka Samhira. These are known as Sarnhitottara Nighantu which prepared a plinth for writing books related to the subject of Dravyaguna. The purpose of writing Nighantu is to make the knowledge of Drugs readily available to the concerned as mentioned by Cakrapani Dutta in the beginning of his book Dravyaguna Sarngraha.
In due course of time, after Sausruta and Astariga Nighantu, many more Nighantus were written by different learned authors between 6th to 17th cent. A.D. Viz.-
Paryayaratnamala, Siddhasara Nighantu, Dhanwantari Nighantu, Indu Nighantu, Candranandana Nighantu, Candra Nighantu, Nimi Nighantu, Haramekhala Nighantu, Dravyaguna Sarngraha, Aruna Datta Nighantu, Vaspacandra Nighantu, Nighantusesa, Sodhala Nighantu, Madhava Dravyaguna, Siddha Mantra, Hrdaya Dipaka, Madanapala Nigha n tu, Kaiyadeo Nighantu, Bhava prakasa Nighantu, Raja Nighantu etc.
Names of more than two hundreds of books related to the subject of Dravyaguna are found in various references but majority of them are either not available or available with much difficulty or anyhow if available, they are found only in Sariskrt langu
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