From the Preface
Cancer-directed gene delivery is the most active area of the field of gene therapy. There are a wide variety of approaches in this major sub-field. Oncolytic viruses, anti-oncogene delivery, suicide gene delivery, dendritic cell antigen loading, T cell delivery, B cell genetic alteration, cytokine gene delivery into cancer cells, siRNA gene delivery, and others, are all active areas within it. All vectors are represented as well; most importantly, adenoviruses, adeno-associated viruses, and retroviruses. The intention was to generate a book which, as much as possible, includes representatives of most of these different anti-cancer approaches, different transgene types, and different vectors. The approach was to provide a platform for active researchers in the field to present wherever they desired, largely without guidance. The contributors did in fact seem to enjoy and embrace this approach. Given this we can expect their favorite subjects will be presented. Reviews were welcome, as were the presentation of new data. Even the use of cancer cells and oncogenes as tools for vector production are discussed. The freedom to write about whatever they wanted was important as such subjects are likely to be the most timely. It is hoped that the readers of this book can confirm and extend what they know about the field of cancer gene therapy, and potentially predict what areas of cancer gene therapy will have the most efficacy in the future. Cancer and Gene Therapy is a snap shot in time of a rapidly developing field which, I think, will continue to be the vangard of gene therapy. I suspect that combinatorial anti-cancer gene therapy treatments will be the final outcome. In any case we hope for the success of all of these approaches and the elimination of morbidity and mortality from this most unmerciful disease.
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