Contemporary Management of Myeloproliferative Neoplasms

 
9789351523628: Contemporary Management of Myeloproliferative Neoplasms
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Myeloproliferative neoplasms (MPN) are a group of blood disorders related to leukaemia in which the body makes too many blood cells. MPN originates in the bone marrow - the soft tissue in the middle of the bones, where all the blood cells are made. In patients with MPN, normal blood cell production breaks down and the bone marrow becomes over-active and makes far too many blood cells. This can cause the blood to become thick. MPN can affect any of the blood cells (red, white and platelets) (Leukemia & Lymphona Research). This book is a comprehensive guide to the diagnosis and management of MPN. Beginning with an introduction, the following chapters examine the diagnostic classification, epidemiology, clinical features and treatment of different types of MPN. A complete chapter is dedicated to hematopoietic stem cell transplant in myelofibrosis. Edited by authoritative experts from Northwestern University Feinberg School of Medicine, Chicago, this useful reference is enhanced by detailed images, illustrations and tables. Key points Comprehensive guide to diagnosis and treatment of myeloproliferative neoplasms Covers diagnostic classification, epidemiology, clinical features and treatment of different types of MPN Complete chapter dedicated to hematopoietic stem cell transplant Edited by recognised experts from Northwestern University Feinberg School of Medicine, Chicago

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Brady L Stein MD MHS Assistant Professor Brandon J McMahon MD Assistant Professor Both at Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

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Book Description Jaypee Brothers Medical Publishers, India, 2015. Hardback. Condition: New. Language: English. Brand new Book. Myeloproliferative neoplasms (MPN) are a group of blood disorders related to leukaemia in which the body makes too many blood cells. MPN originates in the bone marrow - the soft tissue in the middle of the bones, where all the blood cells are made. In patients with MPN, normal blood cell production breaks down and the bone marrow becomes over-active and makes far too many blood cells. This can cause the blood to become thick. MPN can affect any of the blood cells (red, white and platelets) (Leukemia & Lymphona Research).This book is a comprehensive guide to the diagnosis and management of MPN. Beginning with an introduction, the following chapters examine the diagnostic classification, epidemiology, clinical features and treatment of different types of MPN. A complete chapter is dedicated to hematopoietic stem cell transplant in myelofibrosis.Edited by authoritative experts from Northwestern University Feinberg School of Medicine, Chicago, this useful reference is enhanced by detailed images, illustrations and tables.Key pointsComprehensive guide to diagnosis and treatment of myeloproliferative neoplasmsCovers diagnostic classification, epidemiology, clinical features and treatment of different types of MPNComplete chapter dedicated to hematopoietic stem cell transplantEdited by recognised experts from Northwestern University Feinberg School of Medicine, Chicago. Seller Inventory # AAR9789351523628

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Book Description Jaypee Brothers Medical Publishers (P) Ltd., 2015. Hardcover. Condition: New. First edition. This book provides an overview of the diagnostic classification of the MPN, with relevant examples of the histology; this is still critical in establishing a diagnosis, of course complimenting molecular genetic studies. We next provide an overview of relevant contributors to disease pathogenesis, which will provide a background and rationale for the later chapter on novel MPN therapies (Janus kinase-inhibition and others), especially for myelofibrosis (MF). Because thrombotic and bleeding complications can dominate the clinical course during the first decade of disease in essential thrombocythemia (ET) and polycythemia vera (PV), an entire chapter is devoted toward the epidemiology, pathogenic features, risk factors, and management of this set of complications. An in depth review of epidemiology, clinical features, prognosis, and treatment of ET, PV, and MF is provided in chapters 4?6. Because JAK2 V617F is found in virtually all patients with PV, the impact of this mutation is discussed more extensively in chapter 5. Transplantation remains the only curative procedure for the MPN, particularly MF, but the decision to proceed is challenging for physicians and patients alike, and relevant data on prognosis, conditioning regimens, and outcomes are reviewed. Finally, patients with mast cell diseases and hypereosinophilic disorders present challenges in diagnosis and treatment, and the approach to these issues, as well as an update on management of these BCR-ABL negative MPNs is provided in chapters 9 and 10. This book compliments practical aspects of diagnosis and treatment with insights into disease pathogenesis in a rapidly changing landscape, gearing towards students, residents, fellows, and attendings with a special interest in MPN. We hope the readers will agree, and find this book to be a useful tool for the care of their own MPN patients. Key Features Comprehensive overview of diagnostic classification, epidemiology, clinical features, and treatment of the BCR-ABL negative myeloproliferative neoplasms (MPNs), including essential thrombocythemia, polycythemia vera, myelofibrosis, mast cell diseases, and hypereosinophilia Special attention has been paid to thrombosis and hemorrhage in essential thrombocythemia and polycythemia vera, and stem cell transplantation in myelofibrosis Insights into the role of JAK2 V617F, as well as other aspects of disease pathogenesis and progression that establish rationale for a chapter on novel therapeutic strategies Provides a balanced view of both the relevant scientific and therapeutic aspects of the MPNs, complimenting the practical and academic aspects of these diseases Relevant material geared to students, residents, fellows, and attending hematologists with an interest in MPNs. Printed Pages: 204. Seller Inventory # 92612

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Book Description Jaypee Brothers Medical Publishers, India, 2015. Hardback. Condition: New. Language: English . Brand New Book. Myeloproliferative neoplasms (MPN) are a group of blood disorders related to leukaemia in which the body makes too many blood cells. MPN originates in the bone marrow - the soft tissue in the middle of the bones, where all the blood cells are made. In patients with MPN, normal blood cell production breaks down and the bone marrow becomes over-active and makes far too many blood cells. This can cause the blood to become thick. MPN can affect any of the blood cells (red, white and platelets) (Leukemia Lymphona Research). This book is a comprehensive guide to the diagnosis and management of MPN. Beginning with an introduction, the following chapters examine the diagnostic classification, epidemiology, clinical features and treatment of different types of MPN. A complete chapter is dedicated to hematopoietic stem cell transplant in myelofibrosis. Edited by authoritative experts from Northwestern University Feinberg School of Medicine, Chicago, this useful reference is enhanced by detailed images, illustrations and tables. Key points Comprehensive guide to diagnosis and treatment of myeloproliferative neoplasmsCovers diagnostic classification, epidemiology, clinical features and treatment of different types of MPNComplete chapter dedicated to hematopoietic stem cell transplantEdited by recognised experts from Northwestern University Feinberg School of Medicine, Chicago. Seller Inventory # AAR9789351523628

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