Induced Pluripotent Stem Cells in Brain Diseases: Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine (SpringerBriefs in Neuroscience)

0 avg rating
( 0 ratings by Goodreads )
 
9789400728158: Induced Pluripotent Stem Cells in Brain Diseases: Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine (SpringerBriefs in Neuroscience)
View all copies of this ISBN edition:
 
 

Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).

"synopsis" may belong to another edition of this title.

From the Back Cover:

The principle goal of regenerative medicine is the restoration of damaged, dysfunctional, or missing cellular tissue, up to and including whole organs. Growing healthy replacement tissue, in vivo or in vitro, plays an important role in anticipated therapies. To generate competent replacement material, scientists confront the fundamental issues of cellular identity and plasticity.

The basis of this book is formed by the theses of three talented master students: Stephanie Dooves, Dwayne Holmes and Judith Wagner. Their work discusses the recent advancements in the field of cell reprogramming. Although it is clear that we can produce pluripotent stem cells from differentiated cells, there are still a lot of unsolved issues. These issues include the efficiency and safety of reprogramming, the similarity of induced pluripotent (iPSCs) to embryonic stem cells (ESCs) and the epigenetic status of the cells. In the third chapter, the use of stem cell therapy for brain diseases will be discussed, with a focus on Parkinson’s disease (PD) and Vanishing White Matter (VWM).

About the Author:

Dr. Vivi M. Heine is an assistant professor in the Department of Pediatrics of the VU University Medical Center in Amsterdam, Netherlands. Dr. Heine earned her doctoral degree in Neurobiology from the University of Amsterdam, Netherlands. She then received post-doctoral training at the Dana Farber Cancer Institute, Harvard University, Boston and at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California at San Francisco. She obtained a tenure track position in 2010.

"About this title" may belong to another edition of this title.

Top Search Results from the AbeBooks Marketplace

1.

Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner
Published by Springer (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Paperback Quantity Available: 1
Seller:
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Springer, 2011. Paperback. Condition: New. Seller Inventory # DADAX9400728158

More information about this seller | Contact this seller

Buy New
US$ 38.28
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

2.

Vivi M. Heine; Stephanie Dooves; Dwayne Holmes; Judith Wagner
Published by Springer (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Softcover Quantity Available: 1
Seller:
Irish Booksellers
(Portland, ME, U.S.A.)
Rating
[?]

Book Description Springer, 2011. Condition: New. book. Seller Inventory # M9400728158

More information about this seller | Contact this seller

Buy New
US$ 46.92
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

3.

Vivi M. Heine, Stephanie Dooves, Dwayne Holmes
Published by Springer, Netherlands (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Paperback Quantity Available: 1
Seller:
Book Depository International
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2011. Paperback. Condition: New. 2012. Language: English . Brand New Book. Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic memories of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson s disease and Vanishing White Matter (VWM).â. Seller Inventory # LIB9789400728158

More information about this seller | Contact this seller

Buy New
US$ 55.96
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Vivi M. Heine, Stephanie Dooves, Dwayne Holmes
Published by Springer, Netherlands (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Paperback Quantity Available: 1
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2011. Paperback. Condition: New. 2012. Language: English . Brand New Book. Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic memories of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson s disease and Vanishing White Matter (VWM).â. Seller Inventory # LIB9789400728158

More information about this seller | Contact this seller

Buy New
US$ 57.96
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

Vivi M. Heine
Published by Springer (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Quantity Available: > 20
Print on Demand
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Springer, 2011. PAP. Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # IQ-9789400728158

More information about this seller | Contact this seller

Buy New
US$ 62.12
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

6.

M. Heine, Vivi, Stephanie Dooves und Dwayne Holmes:
Published by Springer Netherlands, (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Taschenbuch Quantity Available: 1
Seller:
primatexxt Buchversand
(München, Germany)
Rating
[?]

Book Description Springer Netherlands, 2011. Taschenbuch. Condition: Neu. 59 Seiten Text englisch - neu und ungelesen - NEW, mint - Jeder Lieferung liegt eine ordentliche Rechnung mit ausgewiesener MwSt. bei Sprache: Deutsch Gewicht in Gramm: 160. Seller Inventory # 141563

More information about this seller | Contact this seller

Buy New
US$ 50.09
Convert Currency

Add to Basket

Shipping: US$ 16.36
From Germany to U.S.A.
Destination, Rates & Speeds

7.

Heine, Vivi M.
Published by Springer (2016)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Springer, 2016. Paperback. Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Seller Inventory # ria9789400728158_lsuk

More information about this seller | Contact this seller

Buy New
US$ 64.59
Convert Currency

Add to Basket

Shipping: US$ 5.11
From United Kingdom to U.S.A.
Destination, Rates & Speeds

8.

Vivi M. Heine (author), Stephanie Dooves (author), Dwayne Holmes (author), Judith Wagner (author)
Published by Springer Netherlands 2011-11-23, Dordrecht (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New paperback Quantity Available: 10
Seller:
Blackwell's
(Oxford, OX, United Kingdom)
Rating
[?]

Book Description Springer Netherlands 2011-11-23, Dordrecht, 2011. paperback. Condition: New. Seller Inventory # 9789400728158

More information about this seller | Contact this seller

Buy New
US$ 64.12
Convert Currency

Add to Basket

Shipping: US$ 7.95
From United Kingdom to U.S.A.
Destination, Rates & Speeds

9.

Vivi M. Heine; Stephanie Dooves; Dwayne Holmes
Published by Springer (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Softcover Quantity Available: 1
Seller:
Rating
[?]

Book Description Springer, 2011. Condition: New. Seller Inventory # L9789400728158

More information about this seller | Contact this seller

Buy New
US$ 70.34
Convert Currency

Add to Basket

Shipping: US$ 3.47
From Germany to U.S.A.
Destination, Rates & Speeds

10.

VIVI M. HEINE
Published by Springer (2011)
ISBN 10: 9400728158 ISBN 13: 9789400728158
New Paperback Quantity Available: 1
Seller:
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2011. Paperback. Condition: NEW. 9789400728158 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Seller Inventory # HTANDREE0390949

More information about this seller | Contact this seller

Buy New
US$ 68.22
Convert Currency

Add to Basket

Shipping: US$ 10.60
From United Kingdom to U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book