Islets of Langerhans

ISBN 13: 9789400766853

Islets of Langerhans

0 avg rating
( 0 ratings by Goodreads )
 
9789400766853: Islets of Langerhans

This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.

"synopsis" may belong to another edition of this title.

From the Author:

On Becoming an Islet Researcher At the time of this writing, I have spent a quarter of a century in islet research, butthe purpose of this article is not to share my journey with you. I do not want to boreyou with anecdotes from my experiences, but it is impossible that my views will notbe subjective.Be Clear About Your Goal Irrespective of whether you have started islet research recently, or you have spentalmost a whole life in islet research, it is worthwhile to reflect upon your goals.Here is the big picture. About 194 million people in the world are suffering fromsome form of islet failure, and by 2025 this number may increase to 333 million.The β-cells of many young people and children are dead. To live a normal life,they need to take insulin injections daily, and they need to prick their finger tipsfor testing plasma glucose concentration, numerous times. In others, overwork ofthe β-cells caused by overeating leads to the failure, and eventually to the death ofthese cells. If you want to see the burden of islet failure, do not hesitate to visit anearby diabetes clinic. This may open your eyes, or give you a much neededinsight. Your goal is to contribute to the discovery of something, so that this huge humantragedy can somehow be prevented, treated, or cured. Your goal is not primarily topublish papers or just to do some experiments solely to satisfy your own intellectualcuriosity. Your goal is not just counting the numbers of your publications, and theirimpact factors, and not to secure a promotion, advance your own career, or receiveprizes. You have a bigger goal, which you may or may not reach, within yourlifetime, but if you are conscious of your ultimate goal, you are better prepared towork steadily towards that goal. You may then become the islet researcher that youdream to be. If you wish not to have a clear goal and prefer to see your scientific journey asthe goal, then it is up to you. I think it is important to have visions and goals,perhaps some small goals, if not a big goal to start with.Become the Finest Islet Researcher The making of an islet researcher is not easy. Becoming a good islet researcher canbe a long process. Educate yourself, keeping in mind that it is never too early or toolate to start learning anything new. Through a choice of an unconventional path ofeducation, you may become a specialist in more than one subject, and may thus bebetter prepared. You may first become a molecular biologist, and then educateyourself as a chemist. Numerous other combinations are possible. Enrich yourselfwith the necessary knowledge, and the skills from whatever source you needto. You may need to move to the environments that promote creativity, that havebetter infrastructures, and traditions for good research. To do this, you may need toleave your home country, and then struggle hard to adapt yourself to the newenvironments.You almost certainly need to acquire a broad base of knowledge before youfocus on some special areas. At the same time, you must also be able to filter out asmuch unnecessary information and distractions as possible. In an age of informationpollution, your ability to decide what to filter out, and to filter those outeffectively, may determine how intelligent you are. Clearly, you will not be ableto do many things, at least not at the same time.Start with asking one of the most important questions in the field of isletresearch, keeping in mind that you are expected to discover things that you arenot aware of beforehand. Do not waste time in rediscovering the wheel. If you arenot asking an important question, then it does not matter how sophisticated instrumentor advanced method you are using.Identify your strength, strength of your institution, and that of your network ifyou wish to. Once you have identified the strengths, use those. Do what you think isthe right thing to do without fear of being judged by others, but resist the temptationto work on many projects at the same time; take the one you have started tocompletion. You do not need to compare yourself with others. You do not needto think that you are less talented than others. Do not give up when the goingforward seems tough. Dig as deep as possible or change the direction based on yoursound judgment. See mistakes as valuable learning experiences. If you have time,get inspirations by reading the life histories of other great scientists. From suchreadings, you may get important insights about how to develop your own intuitionand creativity, and about how to get clues about the so called "unknownunknowns."Depending on your question and the nature of the project, you may find it usefulto work alone or with a small dedicated team, or you may need to networkpersonally with a handful of scientists, including some who are not conventionalislet researches. You may benefit more if you attend meetings that do not deal withislet research or if you read papers that do not deal with islet research. If you canbring a small piece of new knowledge from the fields that are very distant from thecontemporary islet research, and apply that knowledge to solve some of thecommon questions in the field of islet research, that may contribute to abreakthrough.Islet research is not just about science, it is a way of life. You have to makedifficult choices during your journey. You are sincere about your purpose in life.At times you may have to juggle with too many bolls in the air. It will affect yoursocial life and your relationships with your near and dear ones. Set your prioritiesright. You have decided to spend your life for the benefit of people who have isletfailure. You are not after money, fame, glamour or festivities. You are a genuineislet researcher.The Ecosystem of Islet ResearchUnfortunately, it is not enough that you have developed yourself as one of the finestislet researchers, and that you have clear visions and goals. The chances ofbreakthroughs in islet research will depend on what we can call the ecosystem ofislet research. The ecosystem of islet research will determines the growth, survival,and creativity of the type of islet researchers that I have alluded to. Importantcomponents of this ecosystem include the educational and research enterprises, thefunding agencies, the governments and policy makers, industries, publishers, andlast but not the least, the patient organizations. The ecosystem of islet research, aswell as the ecosystem of research in general, has changed over the past decades, andit will keep changing. For an individual islet researcher, it may be difficult to trackthese changes, and it may be impossible for them to adapt to the changes that aretaking place rather rapidly. At first sight, it may appear that the ecosystem hasworked well, and has ensured important discoveries at a steady rate. Islet researchersare not supposed to question the ecosystem; the only thing expected of them is toadapt to the changes for their own survival and earn their bread and butter.Survival of the islets researchers depends on their ability to write grant applications,and their ability to convince the people who read those applications that theirideas are excellent and the goals are achievable. Islet researchers spend enormousamount of time, money, and energy on writing grants and in about 80 % of thecases, the applications are rejected. It is impossible to assess who is the mosttalented islet researcher. Since talent cannot be measured, an opportunistic way isto measure what islet researchers have published in the past and how many timesthose publications have been cited. Even if one is able to identify the most talentedislet researchers based on their performances in the past, it is impossible that theseselected islet researchers will perform equally well in the future. Some scientiststhink that the system we have is counter-productive, and wasteful of time andenergy (Garwood 2011).(Please continue reading the rest in the book). 

From the Inside Flap:

ForewordThe tiny islets of Langerhans receive an extraordinary amount of attention from avariety of interested parties, many of whom will enthusiastically welcome publicationof the second edition of the "Islets of Langerhans," ably edited byMd. Shahidul Islam, M.D., Ph.D., of the Karolinska Institute, Stockholm, Sweden.The amount of attention paid to islets is well deserved because the failure of their βcells to produce sufficient amounts of insulin results in diabetes, with its climbingprevalence worldwide and devastating complications. In type 1 diabetes the β cellsare almost completely decimated by the vicious process of autoimmunity. With thefar more common type 2 diabetes, the insulin resistance associated with obesity andour sedentary life style is linked to reduced β cell mass and function. The simplestview is that the β cells die because they are stressed by overwork, resulting inreduction of insulin secretion, which allows glucose levels to rise enough to causefurther impairment of secretion through a process called glucotoxicity. Thus there isa loss of both β cell mass and function, resulting in the concept of decreasedfunctional mass. Most people with insulin resistance never develop type 2 diabetes,which leads to the conclusion the β cell failure is the sine qua non for thedevelopment of the diabetic state.Following from the above, the premise that β cell failure is the root cause ofdiabetes is conceptually very simple, which leads to the conclusion that the diabeticstate should be reversed by administering insulin with injections, restoring β cellfunction with medication or by replenishment of the β cell deficit with transplantationor regeneration. Indeed, the all important proof-of-principle was achieved inthe 1990s with the demonstration that both types 1 and 2 diabetes could be reversedwith islet transplantation either as isolated islets placed in the liver or as wholeorgan pancreas transplants.This second edition of "The Islets of Langerhans" is very timely, because in spiteof the seeming simplicity of the basis of diabetes and progress with β cell replacement,we are still too far from our goal of providing these treatments for those inneed. We need to understand islets on the most basic level so that preclinicaltherapeutic approaches can be explored and then taken to patients. The 49 chaptersin "The Islets of Langerhans" provide up-to-date information on a carefullyselected range of topics.Important Unsolved Islet PuzzlesKnowing full well there are many opinions about which unsolved islet questions aremost important, I will briefly mention a selection of issues that have captured myattention.The islet as an organ: The anatomy of islets is high organized with its cellulararrangements and islet-acinar portal blood flow. We know that β cell secretion has amajor influence on glucagon secretion, but we have much to learn about the otherinteractions between beta, alpha and delta cells and how secretion from all of theseinfluences downstream acinar cell development and maintenance. The role of thepancreatic polypeptide (PP) cells remains very much a mystery.The mystery of glucose-stimulated insulin secretion (GSIS): For years wehave had some understanding of the so-called KATP pathway of GSIS, yet we havelittle understanding of the quantitatively important KATP-independent pathway.This remains a major unsolved problem in β cell biology.Finding new pharmacologic targets for insulin secretion: Many of the chaptersfocus on the cell biology of insulin secretion, and there is much to be learnedabout these very basic facets, such is glucose and fat metabolism, ion and othertransporters, mitochondrial function, calcium handling, phosphorylation reactions,insulin biosynthesis and more. A key question is how much more insulin secretioncan we get out of a β cell? Simply put, if the cell is depolarized and fully stimulatedby cyclic AMP, what approaches can be used to generate more insulin secretion?Dedifferentiation of β cells and islet cell plasticity: The phenotype of β cells inthe diabetic state is deranged and accompanied by dysfunctional insulin secretion,with evidence pointing to glucotoxicity as the major driving force responsible forthese changes. Restoration of normal glucose levels reverse these changes, butquestions remain as to whether these β cells dedifferentiate toward a pluripotentprogenitor state or some other distinct phenotype. The field is now swirling with theconcept of islet cell plasticity, such as the potential alpha and delta cells beingconverted to β cells. There is also a big question about the alpha cell hyperplasiaseen when glucagon action is inhibited: what is the signal of alpha cell growth?The need for more β cells: The β cell deficiency of diabetes could be restored byregeneration of new β cells in the pancreas or by transplanting β cells from someother source. As described in several chapters, this is one of the main priorities indiabetes research. Adult human β cells replicate very slowly but there has beengreat progress in understanding cell cycle mechanisms, which could somehow beexploited. Exciting progress has also be made with making mature β cells fromhuman embryonic stem cells and from induced pluripotent stem cells. There havealso been advances in exploiting the potential of exocrine multipotent progenitorcells and in bioengineering. Porcine cells also remain on the list.Why do β cells die and how can this be prevented? We know that β cells intype 1 diabetes are killed by the immune system, and have watched impressiveadvances in defining the interactions among effector T cells, T regulatory cells,B cells, and the innate immune system. The process is very aggressive and there is agreat need to control it with minimal or no immunosuppression. The Holy Grail isrestoration of tolerance. An old approach receiving renewed attention is encapsulationof islets to protect them from immune killing. The new biomaterials andapproaches are exciting but we cannot yet be confident about its eventual value.In the context of type 2 diabetes much has been written about how β cells die, withmechanisms receiving the most attention being oxidative stress, endoplasmic reticulumstress, toxicity from IAPP oligomers, and the general concept of "overwork."The reality is that the death rate is very low and we have little idea about whichmechanisms are the most important.Of course there are many other important questions, but this sampling fits wellwith the contents of this valuable new edition of "The islets of Langerhans."Its chapters contain important information about these key questions, which makeit likely that hours spent reading this book should help our field connect the criticaldots that will result in new treatments for people with diabetes.Gordon C. Weir, M.D.Co-Head Section on Islet Cell & Regenerative BiologyDiabetes Health and Wellness Foundation ChairJoslin Diabetes CenterProfessor of MedicineHarvard Medical School

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 599.00
US$ 584.99

Convert Currency

Shipping: FREE
From United Kingdom to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Published by Springer, Netherlands (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 10
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2014. Hardback. Book Condition: New. 2nd ed. 2015. Language: English . Brand New Book. This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book. Bookseller Inventory # SPR9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 584.99
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

Published by Springer, Netherlands (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 10
Seller:
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2014. Hardback. Book Condition: New. 2nd ed. 2015. Language: English . Brand New Book. This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book. Bookseller Inventory # SPR9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 589.26
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

3.

M. S. ISLAM
Published by Springer (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 1
Seller:
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2014. Hardback. Book Condition: NEW. 9789400766853 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Bookseller Inventory # HTANDREE0791911

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 579.88
Convert Currency

Add to Basket

Shipping: US$ 10.59
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Islam, Md Shahidul
Published by Springer Verlag (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Quantity Available: 1
Seller:
Paperbackshop-US
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Springer Verlag, 2014. PAP. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Bookseller Inventory # KS-9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 635.08
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

5.

Published by Springer, Netherlands (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 10
Seller:
Book Depository hard to find
(London, United Kingdom)
Rating
[?]

Book Description Springer, Netherlands, 2014. Hardback. Book Condition: New. 2nd ed. 2015. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book. Bookseller Inventory # LIE9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 655.53
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 1
Seller:
AussieBookSeller
(SILVERWATER, NSW, Australia)
Rating
[?]

Book Description 2014. Hardcover. Book Condition: New. 2nd. Hardcover. This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, f.Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. 1415 pages. 2.542. Bookseller Inventory # 9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 630.15
Convert Currency

Add to Basket

Shipping: US$ 37.00
From Australia to U.S.A.
Destination, Rates & Speeds

7.

Islam, Md Shahidul
Published by Springer Verlag (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Quantity Available: 11
Seller:
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Springer Verlag, 2014. PAP. Book Condition: New. New Book.Shipped from US within 10 to 14 business days. Established seller since 2000. Bookseller Inventory # IB-9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 668.11
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

8.

Islam, Md. Shahidul (Editor)
Published by Springer Verlag (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 2
Seller:
Revaluation Books
(Exeter, United Kingdom)
Rating
[?]

Book Description Springer Verlag, 2014. Hardcover. Book Condition: Brand New. 2nd edition. 1415 pages. 9.00x6.25x3.00 inches. In Stock. Bookseller Inventory # __9400766858

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 681.96
Convert Currency

Add to Basket

Shipping: US$ 7.95
From United Kingdom to U.S.A.
Destination, Rates & Speeds

9.

Md. Shahidul Islam
Published by Springer (2014)
ISBN 10: 9400766858 ISBN 13: 9789400766853
New Quantity Available: 11
Seller:
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description Springer, 2014. HRD. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Bookseller Inventory # IB-9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 699.23
Convert Currency

Add to Basket

Shipping: US$ 11.92
From United Kingdom to U.S.A.
Destination, Rates & Speeds

10.

ISBN 10: 9400766858 ISBN 13: 9789400766853
New Hardcover Quantity Available: 1
Seller:
Grand Eagle Retail
(Wilmington, DE, U.S.A.)
Rating
[?]

Book Description Hardcover. Book Condition: New. 2nd. Hardcover. This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet rese.Shipping may be from multiple locations in the US or from the UK, depending on stock availability. 1415 pages. 2.542. Bookseller Inventory # 9789400766853

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 719.22
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book