Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides (New Developments in NMR)

Royal Society of Chemistry

Published by Royal Society of Chemistry, 2014
ISBN 10: 1849739102 / ISBN 13: 9781849739108
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Synopsis: With over thirty years’ experience in this field, the Editors have been active in advancing biological solid-state NMR and have seen applications in biological membranes and whole cells becoming areas of great significance. The ability to study protein and peptides in situ is an exciting development. With contributions from leaders in the field, this book will describe the methodology and applications of solid state NMR spectroscopy to studies of proteins, membrane-active peptides and model biological membranes. As well as structural studies, the Editors aim to include studies of membrane interactions and molecular motions. The book is divided into five main sections: introduction to biological solid-state NMR; applications to biological membranes; membrane proteins; protein complexes and in-cell NMR; and structural studies of amyloid fibrils. The book is essential reading for NMR spectroscopists, analytical chemists and biophysical scientists.

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The complexity and heterogeneity of biological systems has posed an immense challenge in recent years. An increasingly important tool for obtaining molecular and atomic scale information on a range of large biological molecules and cellular components is solid state NMR. This technique can address fascinating problems in structural biology, including the arrangement of supramolecular complexes and fibril formation in relation to molecular folding, misfolding and aggregation.


Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions. A much needed discussion of membrane systems is detailed alongside important developments in in situ analysis.


Topics include applications to biological membranes, membrane active peptides, membrane proteins, protein assemblies and in-cell NMR. This exposition of an invaluable technique will interest those working in a range of related spectroscopic and biological fields. A basic introduction invites those interested to familiarise themselves with the basic mathematical and conceptual foundations of solid state NMR. A thorough and comprehensive discussion of this promising technique follows, which is essential reading for those working or studying at postgraduate level in this exciting field.

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Bibliographic Details

Title: Advances in Biological Solid-State NMR: ...
Publisher: Royal Society of Chemistry
Publication Date: 2014
Binding: Hardcover
Book Condition: Good

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