New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Bookseller Inventory #
Synopsis: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development.
Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.
Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.
This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs. ... provides valuable insights into the great opportunities that are presented by this technology.
―Dr. Kees Fluiter, The University of Amsterdam, in ChemMedChem, Vol. 4, 2009
This edition is a cutting edge document including up-to-date cited references and a variety of compelling clinical case studies, and it of course retains the superb basic principles and background to antisense drug technologies featured in the first edition.
―Gary Evans, Industrial Research Ltd., in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 5
Title: Antisense Drug Technology: Principles, ...
Publication Date: 2007
Book Condition: New
Book Description Condition: New. New. International edition. Different ISBN and Cover image but contents are same as US edition. Perfect condition. Customer satisfaction our priority. Seller Inventory # ABE-DEC-60684
Book Description Condition: Brand New. New. SoftCover International edition. Different ISBN and Cover image but contents are same as US edition. Customer Satisfaction guaranteed!!. Seller Inventory # SHUB60684
Book Description Condition: Brand New. New, SoftCover International edition. Different ISBN and Cover image but contents are same as US edition. Excellent Customer Service. Seller Inventory # ABEUSADEC18-60684
Book Description Softcover. Condition: New. Brand New INTERNATIONAL EDITION, 4-6 days shipping! Same contents as the US edition with 3-5 days shipping. CD/DVD or access codes may not be included. Seller Inventory # 378801
Book Description CRC Press, 2007. Condition: UsedAcceptable. book. Seller Inventory # M0849387965_4
Book Description CRC Press 2007-07-25, 2007. Condition: New. Brand new book, sourced directly from publisher. Dispatch time is 4-5 working days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely. Seller Inventory # NU-TNFPD-00122487
Book Description CRC Press 2007-07-25, 2007. Hardcover. Condition: Good. 2. 0849387965. Seller Inventory # 531912
Book Description CRC Press, 2007. Hardback. Condition: NEW. 9780849387968 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Seller Inventory # HTANDREE0249317
Book Description CRC Pr I Llc, 2007. Hardcover. Condition: Brand New. 2nd edition. 825 pages. 10.00x7.25x2.00 inches. In Stock. Seller Inventory # __0849387965
Book Description CRC Press, 2007. Hardcover. Condition: New. 2. Seller Inventory # DADAX0849387965