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Synopsis: Significant progress has been made in recent years in developing the use of peripheral blood as a source of stem cells for transplantation for patients with haematological and non-haematological malignancies. This book presents an overview of many of the scientific and technical advances that have been made, and discusses the clinical applications and results of transplants with blood-derived stem cells.
From The New England Journal of Medicine: In 1957, E. Donnall Thomas, who later won the Nobel prize, reported on the first attempts to use hematopoietic stem cells as rescue therapy for patients with leukemia who had received high-dose myelotoxic treatment. The source was bone marrow. Although Goodman and colleagues demonstrated in 1962 that pooled blood from donor mice successfully restored hematopoiesis in inbred mice that had received supralethal doses of radiation, there was not much thought among clinicians at that time of using peripheral blood in clinical transplantation. The assumption was that there were too few stem cells in peripheral blood to ensure successful engraftment. No one predicted the explosion in the use of peripheral-blood stem cells for transplantation that would come 20 years later. In the late 1970s and early 1980s, it became evident that peripheral-blood stem cells could be used to repopulate the marrow. The key step in the procedure was (and still is) mobilization of stem cells from marrow to blood. Originally, the stem cells were mobilized by brief treatment with cytotoxic drugs, and the cells were collected during the subsequent rapid recovery phase. For ethical reasons, this method could only be used in the setting of autologous transplantation. However, the discovery that cytokines such as granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor were efficient mobilizers paved the way for the use of peripheral-blood stem cells in the allogeneic setting. The efficiency of mobilization has increased so that now only one or two leukaphereses, each lasting about four hours, are necessary in most cases. Some predict that leukapheresis may not even be necessary in the future. The stem cells in one unit of blood collected after exposure to the right combinations of cytokines at the right time may well be sufficient.
Autologous transplantation in hematologic cancers is not easy to understand. Even in remission, malignant cells are present both in the bone marrow and in the peripheral blood. Dilution and perhaps a selective growth advantage for the normal cells might explain some of the success with autologous transplantation. Gene marking has shown that the transfused cells may cause relapse, and this approach usually has a higher relapse rate than syngeneic or allogeneic transplantation. Therefore, several methods are now used in attempts to purge the bone marrow of malignant cells.
Autologous Stem Cell Transplantation, edited by Angelo Carella, and Blood Stem Cell Transplantation, edited by Josy Reiffers, John Goldman, and James Armitage, are major, comprehensive contributions to the field of blood-cell transplantation. Carella's book is the longer of the two, with 43 chapters and with at least three times as many authors, among them many well-known experts in the field. This work is less a textbook than an update of current knowledge in the field. It focuses on autologous transplantation but briefly covers allogeneic stem-cell transplantation and cord-blood transplantation. The chapter on purification and evaluation of hematopoietic stem cells for transplantation and the excellent review of indications for autologous stem-cell transplantation are highlights of the book.
Blood Stem Cell Transplantation has more of a textbook character. It has only 12 chapters and 33 authors, also some of the best known in the field. It enters somewhat more deeply into explanations and rationales and is probably more valuable for physicians with limited experience in the field. In accordance with the broader title, it more comprehensively covers the fields of allogeneic stem-cell transplantation, cord-blood stem-cell transplantation, and gene therapy. Most of the chapters are excellent, but I value the first two most: "Animal Models," by Georges, Sandmaier, and Storb, and "Characterization of Blood Stem Cells," by Kvalheim and Smeland. Together they provide a comprehensive background for the rest of the book.
There is a good deal of overlap in subject matter between the two books but amazingly little overlap in authors. Only two chapters in each book, those concerning transplantation in multiple myeloma and chronic myelocytic leukemia, have authors in common. These chapters are similar but not exactly the same in both books, probably because of the different approaches of the two books.
The technical approach of Blood Stem Cell Transplantation makes it easier to read than Autologous Stem Cell Transplantation. The former has more illustrations, most of which are good. The sole exceptions are the photographs of the apheresis machines; these should have been better.
Reviewed by Gosta Gahrton, M.D.
Title: BLOOD STEM CELL TRANSPLANTATION
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Book Description Taylor & Francis, 1998. Hardcover. Book Condition: Used: Good. Bookseller Inventory # SONG185317291X
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Book Description Martin Dunitz Ltd, London, United Kingdom, 1997. hardcover. Book Condition: Very Good. Dust Jacket Condition: No Dust Jacket. Significant progress has been made in recent years in developing the use of peripheral blood as a source of stem cells for transplantation for patients with haematological and non-haematological malignancies. This book presents an overview of many of the scientific and technical advances that have been made, and discusses the clinical applications and results of transplants with blood-derived stem cells. The use of blood-derived stem cells is now well-established. This text presents a review of the laboratory and clinical aspects of this technology Size: 8vo - over 7¾" - 9¾" tall. Clean Copy. Bookseller Inventory # 015953
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