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Synopsis: How to conduct clinical trials in an ethical and scientifically responsible manner
This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involving a treatment for hypertension after open heart surgery--and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.
The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Not only do they contribute essays on the scientific, technological, legal, and ethical aspects of clinical trials, but they also critique and debate each other's opinions, creating an interesting, personalized text.
Bayesian Methods and Ethics in a Clinical Trial Design
* Answers commonly raised questions about Bayesian methods
* Describes the advantages and disadvantages of this method compared with other methods
* Applies current ethical theory to a particular class of design for clinical trials
* Discusses issues of informed consent and how to serve a patient's best interest while still obtaining uncontaminated scientific data
* Shows how to use Bayesian probabilistic methods to create computer models from elicited prior opinions of medical experts on the best treatment for a type of patient
* Contains several chapters on the process, results, and computational aspects of the test case in question
* Explores American law and the legal ramifications of using human subjects
For statisticians and biostatisticians, and for anyone involved with medicine and public health, this book provides both a practical guide and a unique perspective on the connection between technological developments, human factors, and some of the larger ethical issues of our times.
From the Publisher: An interdisciplinary group provides essays which explain the nature and methodology of clinical trials through Bayesian techniques. The first section includes a discussion of the ethical debates surrounding clinical trials and the balance between yielding uncontaminated information and protecting the patient's best interest in obtaining and receiving treatment. Part two deals with the test case of verapamil/nitroprusside trial as agents for treating hypertension immediately after open heart surgery. The final segment discusses various legal and related factors of clinical trials.
Title: Bayesian Methods and Ethics in a Clinical ...
Publication Date: 1996
Book Condition: Used: Like New
Book Description Wiley-Interscience, 1996. Hardcover. Book Condition: Good. Great reading/study copy. May have highlights and/or notes. Ships Fast! Satisfaction Guaranteed!. Bookseller Inventory # mon0000580080
Book Description Wiley-Interscience, New York, 1996. Hardcover. Book Condition: Good. First printing. First printing, 1996, hardcover with blue boards, octavo, 318pp., not illustrated. Book good with rubbing, sticker to rear board, binding tight, previous owner's signature to front flyleaf, one page has underlining, otherwise text clean and unmarked. No DJ. Bookseller Inventory # B30489
Book Description Wiley-Interscience, 1996. Hardcover. Book Condition: Used: Very Good. Book has signs of cover wear. Inside pages may have highlighting, writing and/or underlining. Used books may have stickers on them. Ships same day or next business day. Free USPS Tracking Number. Excellent Customer Service. Ships from TN. Bookseller Inventory # 226502
Book Description Wiley-Interscience, 1996. Hardcover. Book Condition: Good. Item may show signs of shelf wear. Pages may include limited notes and highlighting. Includes supplemental or companion materials if applicable. Access codes may or may not work. Connecting readers since 1972. Customer service is our top priority. Bookseller Inventory # mon0001081448
Book Description Wiley-Interscience. Hardcover. Book Condition: Fine. 0471846805 Clean and Unmarked Copy. Bookseller Inventory # TRD000033143
Book Description Wiley-Interscience, 1996. Book Condition: Good. A+ Customer service! Satisfaction Guaranteed! Book is in Used-Good condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear and contain limited notes and highlighting. Bookseller Inventory # 0471846805-2-4
Book Description Wiley-Interscience, 1996. Hardcover. Book Condition: Used: Good. Bookseller Inventory # SONG0471846805
Book Description Wiley-Interscience, 2017. Hardcover. Book Condition: Very Good. Great condition with minimal wear, aging, or shelf wear. This item is printed on demand. Bookseller Inventory # P020471846805
Book Description John Wiley & Sons, New York, 1996. Hardcover. Book Condition: Near Fine. First printing. First edition, 1996. Hardcover, 318 pp., Very Good copy, some highlighting to the text, a bit of discoloration to the outer pages and page-edges, a faint odor to the book, no dust jacket. Bookseller Inventory # s0008713
Book Description Wiley-Interscience, 2017. Hardcover. Book Condition: New. Never used! This item is printed on demand. Bookseller Inventory # P110471846805