Bayesian Methods and Ethics in a Clinical Trial Design

Kadane, Joseph B. [Editor]

Published by Wiley-Interscience, 1996
ISBN 10: 0471846805 / ISBN 13: 9780471846802
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Synopsis: How to conduct clinical trials in an ethical and scientifically responsible manner

This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case--involving a treatment for hypertension after open heart surgery--and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.

The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Not only do they contribute essays on the scientific, technological, legal, and ethical aspects of clinical trials, but they also critique and debate each other's opinions, creating an interesting, personalized text.

Bayesian Methods and Ethics in a Clinical Trial Design
* Answers commonly raised questions about Bayesian methods
* Describes the advantages and disadvantages of this method compared with other methods
* Applies current ethical theory to a particular class of design for clinical trials
* Discusses issues of informed consent and how to serve a patient's best interest while still obtaining uncontaminated scientific data
* Shows how to use Bayesian probabilistic methods to create computer models from elicited prior opinions of medical experts on the best treatment for a type of patient
* Contains several chapters on the process, results, and computational aspects of the test case in question
* Explores American law and the legal ramifications of using human subjects
For statisticians and biostatisticians, and for anyone involved with medicine and public health, this book provides both a practical guide and a unique perspective on the connection between technological developments, human factors, and some of the larger ethical issues of our times.

From the Publisher: An interdisciplinary group provides essays which explain the nature and methodology of clinical trials through Bayesian techniques. The first section includes a discussion of the ethical debates surrounding clinical trials and the balance between yielding uncontaminated information and protecting the patient's best interest in obtaining and receiving treatment. Part two deals with the test case of verapamil/nitroprusside trial as agents for treating hypertension immediately after open heart surgery. The final segment discusses various legal and related factors of clinical trials.

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Title: Bayesian Methods and Ethics in a Clinical ...
Publisher: Wiley-Interscience
Publication Date: 1996
Binding: Hardcover
Book Condition: Used: Like New

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