Bile Acids: From Genomics to Disease and Therapy (Hardcover)

U. Leuschner

Published by Springer, 2003
ISBN 10: 0792387813 / ISBN 13: 9780792387817
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Hardcover. Since the International Bile Acid Meeting in The Hague in 2000, bile acid research has continued to flourish and therapeutic use of bile acids has attained a broader role. Bile acid resear.Shipping may be from multiple locations in the US or from the UK, depending on stock availability. 300 pages. 0.626. Bookseller Inventory # 9780792387817

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Since the last International Bile Acid Meeting in The Hague in 2000, bile acid research has continued to flourish and therapeutic use of bile acids has attained a broader role. Bile acid research has been stimulated by the discovery that bile acids specifically bind to receptors of the cell nucleus. Thereby, they regulate the transcription of transport proteins and enzymes involved in synthesis, transport and metabolism of bile acids and maintain cholesterol homeostasis. Knowledge about genetic defects of bile acid transport which may cause cholestasis or intestinal malabsorption has also increased impressively. Therapy of chronic cholestatic liver diseases, especially of primary biliary cirrhosis, with ursodeoxycholic acid represents an important advance in modern hepatology and has stimulated basic and clinical research to unravel the underlying mechanisms of action and to optimize treatment schedules.

This book is the proceedings of Falk Symposium 129, the XVII International Bile Acid Meeting held in Freiburg, Germany, May 30-June 1, 2002, which was again dedicated to both basic and clinical aspects of bile acid research with a focus on the role of bile acids in hepatobiliary and intestinal diseases. The latest findings are presented by the leading scientists and clinicians in the field.

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Title: Bile Acids: From Genomics to Disease and ...
Publisher: Springer
Publication Date: 2003
Binding: Hardcover
Book Condition: New
Edition: 03200th.

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G. Paumgartner; D. Keppler; U. Leuschner; A. Stiehl
Published by Kluwer Academic Publishers (2003)
ISBN 10: 0792387813 ISBN 13: 9780792387817
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Book Description Kluwer Academic Publishers, 2003. Hardcover. Condition: Very Good. Dust Jacket Condition: Very Good. 1st Edition. Hardcover, xvi + 293 pages, NOT ex-library. Clean and bright throughout, with unmarked text, free of inscriptions and stamps; firmly bound. Dust jacket with a heavily sunned spine, else very good, untorn, clean, showing minor handling wear. -- Proceedings of Falk Symposium 129 dedicated to basic and clinical aspects of bile acid research with a focus on the role of bile acids in hepatobiliary and intestinal diseases. The latest findings are presented by the leading scientists and clinicians in the field. -- Contents: Adolf Windaus Prize Lecture: Enzymes & Genes of Bile Acid Synthesis; I: Regulation of Gene Expression by Bile Acids: 1 Homeostatic Control of Bile Acid Biosynthesis & Transport by Nuclear Receptors 2 Crosstalk Between Nuclear Receptor & Cytokine-Activated Pathways in the Regulation of Ntcp Gene Expression 3 Transactivation of the Human OATP8 Gene by the Farnesoid X Receptor/Bile Acid Receptor (FXR/BAR); II: Synthesis & Metabolism of Bile Acids: 4 Vitamin D Receptor as a Bile Acid Sensor 5 Molecular Mechanisms of Nuclear Receptor Regulation of Bile Acid Synthesis 6 Manipulating the Bile Acid Pool Regulates CYP7A1 by Changing FXR Activation 7 Role of Mitochondrial Cholesterol Transport in Bile Acid Biosynthesis 8 Regulation of Bile Acid Formation in the Human Liver; III: Transport of Bile Acids & Bile Secretion: 9 Mutations in the Sodium-Independent Bile Salt Uptake Transporter of Human Liver SLC21A6 10 Regulation of the Rat Organic Anion Transporting Polypeptide 4 (Oatp4) by Bile Acids 11 Function & Regulation of Expression of the Canalicular Bile Salt Export Pump 12 Function of BSEP 13 Sinusoidal Efflux of Bile Acids via Mrp3 (ABCC3) 14 Organ-Specific Regulation of Nuclear Hormone Receptors & Bile Salt Transport Proteins in Obstructive Cholestasis 15 Effects of Bile Salt Flux Variations on the Expression of Hepatic Bile Salt Transporters in vivo in Rodents 16 Cloning & Characterization of Rat Bile Salt Export Pump Promoter: Bile Acid Activation is Mediated via Farnesoid X Receptor/Bile Acid Receptor 17 Effect of Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC-2) Mutations on Functioning of the Bile Salt Export Pump 18 Short-Term Regulation of Bile Secretion 19 Taurolithocholic Acid Impairs Bile Secretion by Phosphatidylinositol 3-Kinase- & Protein Kinase Ce-Dependent Mechanisms 20 Mouse Models of Intestinal Bile Acid Malabsorption 21 Characterization & Identification of the Intestinal Cholesterol Uptake System; IV: Bile Acids in Disease: 22 Acquired Alterations of Hepatobiliary Transport Systems in Human Cholestatic Liver Diseases: Potential Targets of Pharmacotherapy 23 Biliary Lipid Composition in Benign Recurrent Intrahepatic Cholestasis 24 Mutations in MDR3 in Adult Onset Cholangiopathy 25 MDR3 Gene Mutations & Cholesterol Cholelithiasis 26 Expression & Localization of Hepatocellular Transporters & Radixin in Primary Biliary Cirrhosis 27 Neonatal Liver Disease in Two Siblings Caused by a Failure to Racemize (25r)Trihydroxy-Cholestanoic Acid Due to a Gene Mutation in 2-Methylacyl-CoA Racemase: Effectiveness of Cholic Acid Therapy in Preventing Liver & Neurological Disease; V: Bile Acids in Therapy: 28 UDCA & TUDCA Ameliorate Hepatocyte Damage Caused by EtOH & Acetaldehyde by Different Mechanisms 29 Ursodeoxycholic Acid Therapy Affects the Cytokine Network & Plays an Immunomodulatory Role in Patients with Primary Sclerosing Cholangitis & Primary Biliary Cirrhosis 30 Dose Response of UDCA in the Treatment of Cholestatic Disorders 31 High Dose Ursodeoxycholic Acid in the Management of Primary Sclerosing Cholangitis 32 Intrahepatic Cholestasis of Pregnancy: Placebo Controlled Randomised Trial of Ursodeoxycholic Acid vs Dexamethasone on Maternal & Fetal Outcome & Metabolism 33 Ursodeoxycholic Acid in the Chemoprevention of Colon Cancer 34 Tauroursodeoxycholic Acid for the Treatment of Acute & Chronic Neurodegenerative Diseases; Index. Seller Inventory # 004689

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G. Paumgartner (Editor), D. Keppler (Editor), U. Leuschner (Editor), A. Stiehl (Editor)
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Editor-G. Paumgartner; Editor-D. Keppler; Editor-U. Leuschner; Editor-A. Stiehl
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Book Description Springer, Netherlands, 2003. Hardback. Condition: New. 2003 ed. Language: English. Brand new Book. Since the last International Bile Acid Meeting in The Hague in 2000, bile acid research has continued to flourish and therapeutic use of bile acids has attained a broader role. Bile acid research has been stimulated by the discovery that bile acids specifically bind to receptors of the cell nucleus. Thereby, they regulate the transcription of transport proteins and enzymes involved in synthesis, transport and metabolism of bile acids and maintain cholesterol homeostasis. Knowledge about genetic defects of bile acid transport which may cause cholestasis or intestinal malabsorption has also increased impressively. Therapy of chronic cholestatic liver diseases, especially of primary biliary cirrhosis, with ursodeoxycholic acid represents an important advance in modern hepatology and has stimulated basic and clinical research to unravel the underlying mechanisms of action and to optimize treatment schedules. This book is the proceedings of Falk Symposium 129, the XVII International Bile Acid Meeting held in Freiburg, Germany, May 30-June 1, 2002, which was again dedicated to both basic and clinical aspects of bile acid research with a focus on the role of bile acids in hepatobiliary and intestinal diseases. The latest findings are presented by the leading scientists and clinicians in the field. Seller Inventory # LIE9780792387817

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G. Paumgartner D. Keppler U. Leuschner A. Stiehl
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