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Biomineralization: Medical Aspects Of Solubility

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ISBN 10: 0470092092 / ISBN 13: 9780470092095
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Title: Biomineralization: Medical Aspects Of ...

Binding: Hardcover

Book Condition:New

About this title


This title takes an interdisciplinary approach to the central role of solubility in pathological biomineralisation, ranging from traditional thermodynamics and kinetics to unusual concepts such as the PILP process. The scientific background and expertise of the contributors, ranges accordingly from solubility modelling and database development, renal stone and bone implant research, Mössbauer spectroscopy and structural chemistry to biochemistry and crystallisation. The chapters all have a quantitative, physico-chemical component rather than giving purely phenomenological descriptions. The contributors deal with aspects and concepts that have not previously been common in the study of pathological biomineralisation processes.

From the Back Cover:

Solubility phenomena are fundamental to living organisms and rangefrom gas solubilities (e.g. oxygen in blood) to biomineralformation in body fluids. This book comprises five chapters onvarious perspectives of normal and pathological biomineralizationin humans.

Chapter 1 gives an overview of experimental and modelingmethods, recommends solubility data for selected stone-formingsubstances and describes recently discovered, unusual dissolutionand crystallization phenomena involving nano-sizedbiomaterials.

Chapter 2 presents a general classification of renal andsalivary calculi based on their formation mechanism.

Chapter 3 reviews the solubilities of calcium and magnesiumphosphates and discusses their relevance to normal and pathologicalmineralization in terms of stability field diagrams.

Chapter 4 proposes a new paradigm for biomineralization - liquidphase precursors - and their possible roles in the formation ofbone and kidney stones.

In Chapter 5, various aspects of the biomineralization of ironand its relation to iron overload diseases are discussed.

Aimed at chemists interested in solution chemistry,thermodynamics, kinetics, crystallisation, biochemistry,biomineralisation, medicinal chemistry and industrial chemistry,this book is also relevant to doctors and biologists interested inresearch in urology, nephrology, clinical chemistry and chelationtherapy.

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