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Bone Metastasis: Mechanisms and Pathophysiology

Orr; Singh

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ISBN 10: 0412103419 / ISBN 13: 9780412103414
Published by Chapman & Hall, 1996
Used Condition: Near Fine Hardcover
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Bibliographic Details

Title: Bone Metastasis: Mechanisms and ...

Publisher: Chapman & Hall

Publication Date: 1996

Binding: Hardcover

Book Condition:Near Fine

About this title

Synopsis:

A multi-authored volume that focuses on the significant advances made over the last decade in elucidating a variety of mechanisms which are involved in the process of bone metastasis. The authors are all active investigators and review the current state of knowledge in their areas of research. The first section deals with interactions between cancer cells and the microenvironment in bone. Further sections address the response of bone to local or systemic mediators of osteolysis released by tumor tissue, and describe experimental models of bone metastasis with an emphasis on prostate cancer and the use of these models to evaluate therapeutic strategies. Distributed by Chapman & Hall. Annotation c. by Book News, Inc., Portland, Or.

From the Back Cover:

Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation.
State-of-the-art and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involved-whether in research or clinical treatment of bone-seeking cancers-the biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.

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