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The Centromere

K. H. Andy Choo

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ISBN 10: 019857780X / ISBN 13: 9780198577805
Published by Oxford University Press
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Paperback. 320 pages. Dimensions: 9.1in. x 6.0in. x 0.8in.The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advances have been made in our understanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in detail the DNA and protein components of this structure, and their individual functions, in species as diverse as budding and fission yeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling passenger proteins; important emerging concepts such as latest centromeres and epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application of centromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9780198577805

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Bibliographic Details

Title: The Centromere

Publisher: Oxford University Press

Binding: Paperback

Book Condition: New

Book Type: Paperback

About this title

Synopsis:

The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advances have been made in our understanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in detail the DNA and protein components of this structure, and their individual functions, in species as diverse as budding and fission yeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling "passenger" proteins; important emerging concepts such as latest centromeres and epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application of centromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject.

About the Author:

K. H. Andy Choo is at The Murdoch Institute for Research into Birth Defects, Melbourne.

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