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Circulating Nucleic Acids in Plasma and Serum IV, Volume 1075 (Annals of the New York Academy of Sciences) (v. 4)


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ISBN 10: 157331627X / ISBN 13: 9781573316279
Published by Wiley-Blackwell, 2006
New Condition: New Soft cover
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Title: Circulating Nucleic Acids in Plasma and ...

Publisher: Wiley-Blackwell

Publication Date: 2006

Binding: Paperback

Book Condition:New

Edition: 1.

About this title


An accurate, inexpensive, and noninvasive method for the earlydiagnosis of cancer has been something of a holy grail among cancerresearchers, but until recently a method meeting all three criteriahas been elusive. Nucleic acids were first discovered incirculation in 1948, but it was not until the 1960s and 70s thatpatients with autoimmune disease and cancer were discovered to havehigher levels of circulating DNA than were detected in in healthypersons.

The focus in this volume is on three major applications of thecirculating nucleic acids detection method: cancer, fetal medicine,and diseases such as diabetes, stroke, and myocardial infarction.In addition, there are reports on the biology and origins ofcirculating DNA and RNA and on improved methods for the detectionof nucleic acids in plasma and serum.

The circulating DNA found in cancer patients has manycharacteristics in common with their tumors, which made it anattractive candidate for use in the diagnosis and management ofpatients with malignancies. This method can also be applied to theassessment of the sublinical tumor burden in cancer patients, thusreducing the risk of unnecessary chemotherapy.

Detection of nucleic acids circulating in maternal serum meansthat fetal diagnosis may be possible without resorting to the moredangerous and invasive methods now used (e.g., amniotic fluid andchorionic villus sampling). Detection of problems in the pregnancysuch as preeclampsia and intrauterine growth retardation may alsobecome possible through maternal blood samples.

In diabetic patients, circulating nucleic acids can be used forthe early detection of developments such as retinopathy.

The benefits of using circulating nucleic acids in the diagnosisand management of cancer and chronic disease will be realizedthrough earlier detection by means of this less expensive and lessinvasive testing technique and through its potential for closermonitoring of the disease.

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