Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

Rowland, Malcolm

Published by LWW
ISBN 10: 8184733984 / ISBN 13: 9788184733983
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Synopsis: Formerly clinical pharmacokinetics: concepts and applications, this fully updated fourth edition has been retitled clinical pharmacokinetics and pharmacodynamics: concepts and applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject. Key features: new! key relationships section at end of each chapter highlights the core mathematical concepts presented and aids students in solving the review problems. New! expanded coverage of topical areas, including (1) integration of pharmacokinetics with pharmacodynamics (2) molecular and mechanistic processes as they relate to pharmacokinetics of drugs (3) individual variations in drug response (4) role of enzymes, transporters and genetics (5) new sections on turnover concepts and dialysis. New! interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters. New! chapter 21: protein drugs, reflecting the rapid increase in recent years in the number of such medicines that have become a part of the armamentarium of modern therapeutics. New! chapter 22: prediction and refinement of human kinetics from in vitro, preclinical and early clinical data, concepts that improve the chances of ing compounds that have desirable pharmacokinetic characteristics and help ensure their subsequent optimal use. Learning objectives and study problems, with answers and detailed explanations at the end of the book.

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Title: Clinical Pharmacokinetics and ...
Publisher: LWW
Binding: Paperback

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