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Directed Evolution of the Aspergillus niger Epoxide Hydrolase

Li-Wen Wang

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ISBN 10: 3639060156 / ISBN 13: 9783639060157
Published by VDM Verlag
New Condition: New Soft cover
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Paperback. 100 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Darwinian Evolution of an enzyme You might wonder, whats thisGenetic Evolution of a biocatalyst, scientifically known as directed evolution has emerged in last decade thanks to great advances in molecular biology as a very powerful tool to genetically manipulate an enzyme either to improve enzyme properties to switch the selectivity or to create a completely new catalyst. Epoxides are versatile building blocks for natural product synthesis. Quoting Prof. Seebach: If carbonyl compounds have been said to be virtually the backbone of organic synthesis the epoxides correspond to at least one of the main muscles this emphasized the importance of these compounds. Epoxide hydrolases are useful biocatalysts to obtain optically enriched epoxides. This work applied directed evolution as a strategy to improve the enantioselectivity of an epoxide hydrolase. Different selection and screening methods were established. . . What about the final result Take a look you will find out! This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783639060157

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Bibliographic Details

Title: Directed Evolution of the Aspergillus niger ...

Publisher: VDM Verlag

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Darwinian Evolution of an enzyme?? You might wonder, what's this??Genetic Evolution of a biocatalyst, scientifically known as directed evolution" has emerged in last decade thanks to great advances in molecular biology as a very powerful tool to genetically "manipulate" an enzyme either to improve enzyme properties to switch the selectivity or to create a completely new catalyst.Epoxides are versatile building blocks for natural product synthesis. Quoting Prof. Seebach: "If carbonyl compounds have been said to be virtually the backbone of organic synthesis the epoxides correspond to at least one of the main muscles" this emphasized the importance of these compounds. Epoxide hydrolases are useful biocatalysts to obtain optically enriched epoxides.This work applied directed evolution as a strategy to improve the enantioselectivity of an epoxide hydrolase. Different selection and screening methods were established... What about the final result? Take a look you will find out!"

About the Author:

Li-Wen Wang was born in Taipei, Taiwan, on March 29th 1976. After obtaining her B.S. and M.Sc. in Chemical Engineering at the National Cheng-Kung University in Taiwan, she was granted a DAAD stipend to pursue her Ph.D. study at the Max-Planck-Institut fuer Kohlenforschung in Muelheim an der Ruhr, Germany.

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