Stock Image

Drug Targeting: Strategies, Principles, and Applications (Methods in Molecular Medicine, Volume 25)

G. E. Francis , Cristina Delgado, eds.

0 ratings by Goodreads
ISBN 10: 089603531X / ISBN 13: 9780896035317
Published by Humana Press, 2000
Used Condition: Good
From Zubal-Books (Cleveland, OH, U.S.A.)

Heritage Bookseller
AbeBooks Member Since 1996

Quantity Available: 1

Buy Used
Price: US$ 3.62 Convert Currency
Shipping: US$ 3.50 Within U.S.A. Destination, Rates & Speeds
Add to basket

30 Day Return Policy

About this Item

318 pp., hardcover, ex library, else text and binding clean, tight, and bright. Bookseller Inventory # ZB466214

Ask Seller a Question

Bibliographic Details

Title: Drug Targeting: Strategies, Principles, and ...

Publisher: Humana Press

Publication Date: 2000

Book Condition:Good

About this title


Advances in understanding the molecular mechanisms of disease together with the advent of recombinant DNA and other technologies have opened opportunities for a vast array of novel therapeutic biopharmaceuticals and diagnostic agents. However, even natural biomolecules present a myriad of problems that limit their potential as pharmaceutical agents. Rapid degra- tion and elimination, immunological reactions, and toxicity are often asso- ated with new biopharmaceuticals, much as with conventional agents. Targeted delivery systems have the potential to increase the efficacy of existing diagnostic and therapeutic agents and also create an opportunity for the use of new pharmaceuticals, substances that themselves can be harmful to normal tissues. Both passive and active targeting have been exploited. Most active targ- ing strategies have focused on antibody conjugates since preparation of highly specific monoclonal antibodies is well established. However, a new wave of c- jugates exploiting other ligands is underway. Access to the target tissue remains an obstacle and is an area where passive targeting can be useful. In Drug Targeting: Strategies, Principles, and Applications we have tried to compile a state-of-the-art volume on current targeting approaches. The first section focuses on certain key strategies applied to date, and how to build the antibody– ligand constructs. This is followed by a section on theoretical considerations for t- geting, focusing on approaches relevant to solid tumors. The last section deals with some experimental and clinical applications of targeted drug delivery systems.

From the Back Cover:

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies. In addition to providing detailed step-by-step instructions, the highly experienced authors review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also presented are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium, as well as methods addressing both the active and passive targeting of tumors.
Comprehensive and innovative, Drug Targeting: Strategies, Methods, and Protocols documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

"About this title" may belong to another edition of this title.

Store Description

Zubal Books is the #1 buyer and seller of scholarly and rare books in America. Since 1961 we've handled thousands of private and technical libraries. Our family business knows books and we treat our clients with top-notch customer service. If you have any questions about our listings, please don't hesitate to contact us.

Visit Seller's Storefront

Terms of Sale:

Price are net to all
Visa/MC/Check/Money Order
Libraries Invoiced

We do accept checks, however

All international postal rates are subject to change depending on weight
and size.

Shipping Terms:

Orders usually ship within 2 business days. Shipping costs are based on books
weighing 2.2 LB, or 1 KG. If your book order is heavy or oversized, we may
you to let you know extra shipping is required.

List this Seller's Books

Payment Methods
accepted by seller

Visa Mastercard American Express