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Essential Concepts in Toxicogenomics

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ISBN 10: 1617376884 / ISBN 13: 9781617376887
Published by Humana Press Inc.
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277 pages. Dimensions: 9.2in. x 6.1in. x 0.7in.The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook. Instead, wechose to identify experts in all aspects of this field and challenged them to write reviews, opinion pieces, and case studies. This book covers the main areas important to the study and use of toxicogenomics. Chapter 1 speaks to the convergenceofclassicapproachesalongsidetoxicogenomics. Chapter2deals withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity. Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics experiments, as well as the implications of using microarrays as diagnostic devices. The need for appropriate statistical approaches to genomic data is discussed in Chapter 4, and Chapters 5 and 6 describe the use of genomic datatobuildtoxicogenomicmodelsandprovideinsightsfromtheapproaches oftwocompanies. Theimportanttopicofstoringthedatageneratedinsuch experiments and the correct annotation that must accompany such data is considered in Chapter 7. The discussion in Chapter 8 speaks to the use of toxicogenomicstoidentifyspeciessimilaritiesanddifferences. Chapters9and 10dealwiththeuseofgenomicstoidentifybiomarkerswithinthepreclinical andclinicalarenas. Biomarkerswillonlybeusefulifthecommunityatlarge acceptsthemasmeaningful. Consortiaareimportanttodrivethisfunction, and Chapter11discussescurrenteffortsinthisarea. Lastbutnotleast, Chapter12 presentsaperspectiveontheregulatoryimplicationsoftoxicogenomicdataand someofthehurdlesthatcanbeseeninitsimplicationinGLPstudies. Although thisbooktendstofocusonpharmaceuticals, theissuesfacingtoxicologyare sharedbythechemicalmanufacturers, thetobaccoindustry, andtheirregulators. We want to thank our contributors for their generous time and energy in providingtheirinsights. Sadly, wemustnotetheunexpectedpassingofone ofourauthors, Dr. JosephHackettoftheFDA. Joescontributionservesasa testimonytohisaccomplishmentsinthisfield, andhisinsightwillbemissed intheyearstocome. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9781617376887

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Bibliographic Details

Title: Essential Concepts in Toxicogenomics

Publisher: Humana Press Inc.

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title


The field of toxicogenomics has been growing quickly. This informative and cutting-edge book collects reviews, opinion pieces and case studies from this dynamic field with a focus on its application to pharmaceuticals.

From the Back Cover:

The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field.  Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals.  Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series.


Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.

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