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Graves? Disease: Pathogenesis and Treatment (Endocrine Updates)


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ISBN 10: 1461369835 / ISBN 13: 9781461369837
Published by Springer, 2012
Condition: Good Soft cover
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Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be ex-library. Shipping & Handling by region. Buy with confidence, excellent customer service! Softcover reprint of the original 1st ed. 2000. Bookseller Inventory # 1461369835

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Title: Graves? Disease: Pathogenesis and Treatment ...

Publisher: Springer

Publication Date: 2012

Binding: Paperback

Book Condition: Good

About this title


From the perspective of the investigator, Graves' disease is a fascinating disorder with unique features and opportunities for study. The discovery in 1956 that Graves' disease was caused by a humoral factor, later shown to be an antibody to the TSH receptor, was a triumph for modern investigative medicine. Rapid progress is now being made in (i) understanding the molecular interaction between autoantibodies and the TSH receptor, (ii) identifying the genes that contribute to the predisposition to disease, (iii) developing an animal model of Graves' disease, and (iv) identifying the long-sought orbital antigen in ophthalmopathy. From the clinical standpoint, although Graves' disease is eminently treatable, there is no definitive cure. None of the therapeutic options are ideal. It is hoped that rapid progress in understanding the pathogenesis of the disease will lead to the ultimate goal of some form of immunotherapy that will make antithyroid drugs, radioiodine and thyroidectomy obsolete. <br /> The chapters in <em>Graves' Disease: Pathogenesis and Treatment</em> represent the viewpoints of many prominent clinicians and investigators working in the field. The editors are grateful for their contributions which cover an unusually comprehensive compendium of subjects relating to the disease.

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