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Haptotaxis in Tumour Growth and Invasion: A Mathematical Modelling Approach

Daniel Mallet

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ISBN 10: 3639061454 / ISBN 13: 9783639061451
Published by VDM Verlag Dr. Müller, 2008
Used Condition: Good Soft cover
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Bibliographic Details

Title: Haptotaxis in Tumour Growth and Invasion: A ...

Publisher: VDM Verlag Dr. Müller

Publication Date: 2008

Binding: Paperback

Book Condition:Good

About this title

Synopsis:

In this work, a number of mathematical models ofhaptotactic cell migration are developed. Thesemodels of haptotaxis are presented in two distinctparts – the first comprises an investigation ofhaptotaxis in pre–necrotic avascular tumours, while the second consists of the modelling ofadhesion–mediated haptotactic cell migration withintissue, with particular attention paid to thebiological appropriateness of the description ofcell–extracellular matrix adhesion. A model isdeveloped that describes the effects of passive andactive haptotactic migration on the cellular dynamicsand growth of pre–necrotic avascular tumours. Thismodel is also extended to describe theinternalisation of labelled cells and inertmicrospheres within multicell tumour spheroids. Alsopresented is a novel model of adhesion–receptormediated haptotactic cell migration. Specificapplications of the model to tumour invasionprocesses are then discussed. This model includes amore biologically realistic description of celladhesion than has been considered in previous modelsof cell population haptotaxis.

About the Author:

Daniel (Dann) Mallet is a Lecturer in Applicable Mathematics atthe School of Mathematical Sciences at Queensland University ofTechnology, Brisbane, Australia. His main research interests arein mathematical modelling of biological cells and associatedphenomena such as migration, growth and infectious diseases.

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