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Hepatitis C Virus Antigen Cellular Response to HLA Class 1 Allele

Chinmaya Mahapatra

ISBN 10: 3847330608 / ISBN 13: 9783847330608
Published by LAP Lambert Academic Publishing
New Condition: New Soft cover
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Paperback. 80 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Clinical and virological outcomes are variable following acute infection with HCV. Chronic infection is characterized by attenuated and narrowly focused CD4 and CD8 T-cell responses in conjunction with reduced proliferative, cytokine, and cytolytic capacity of HCV-specific T cells and loss of antigen recognition. Conversely, CD4 and CD8 T-cell responses are maintained in individuals who clear the virus. Therefore, effective T-cell-dependent immune responses to HCV-specific viral epitopes, restricted by the presence of host human leukocyte antigens (HLA) class I (CD8 cytotoxic T cells CTL) and class II (CD4 helper T cells), appear to make an important contribution to adaptive immunity and disease outcome. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783847330608

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Bibliographic Details

Title: Hepatitis C Virus Antigen Cellular Response ...

Publisher: LAP Lambert Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Clinical and virological outcomes are variable following acute infection with HCV. Chronic infection is characterized by attenuated and narrowly focused CD4+ and CD8+ T-cell responses in conjunction with reduced proliferative, cytokine, and cytolytic capacity of HCV-specific T cells and loss of antigen recognition. Conversely, CD4 and CD8 T-cell responses are maintained in individuals who clear the virus. Therefore, effective T-cell-dependent immune responses to HCV-specific viral epitopes, restricted by the presence of host human leukocyte antigens (HLA) class I (CD8 cytotoxic T cells [CTL]) and class II (CD4 helper T cells), appear to make an important contribution to adaptive immunity and disease outcome.

About the Author:

I am currently a PhD student with fellowship from DBT and woring in the field of Tissue Engineering in Dept. of Biotechnology & Medical Engineering, National Institute of Technology Rourkela ,India. I have completed my Master in M.Tech Biotechnology from Dr.D.Y Patil University,Pune, India with my final year research from NIV ,Pune ,India.

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