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Iron Metabolism: From Molecular Mechanisms to Clinical Consequences

Robert Crichton

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ISBN 10: 1118925610 / ISBN 13: 9781118925614
Published by Wiley, 2016
Condition: Good Hardcover
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Bibliographic Details

Title: Iron Metabolism: From Molecular Mechanisms ...

Publisher: Wiley

Publication Date: 2016

Binding: Hardcover

Book Condition: Good

Edition: 4.

About this title

Synopsis:

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems  a natural target for  pathogenic microorganisms and parasites. Uniquely, humans  suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is  associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health.
The 4th edition of Iron Metabolism  is written in a lively style by one of the leaders in the field, presented in colour  and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

From the Back Cover:

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development.

Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, Third Edition presents a comprehensive overview of this important field. topics covered include:

  • Solution chemistry of iron in biological media
  • The importance of iron for biological systems
  • Microbial iron transport and metabolism
  • Iron uptake by plants and fungi
  • Cellular iron uptake and export in mammals
  • Intracellular iron storage and biomineralization
  • Intracellular iron metabolism and cellular iron homeostasis
  • Iron absorption in mammals,with particular reference to man, and regulation of systemic iron balance
  • Pathophysiology of iron deficiency and iron overload in man
  • Iron and oxidative stress
  • Brain iron homeostasis and its pertubation in various neurodegenerative diseases
  • Interactions between iron and other metals

Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer's disease.

Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

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