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Liver Protective Effects of Eleusine Indica and Thysanolaena Latifolia

Mohammad Iqbal

ISBN 10: 3846533858 / ISBN 13: 9783846533857
Published by LAP LAMBERT Academic Publishing
New Condition: New Soft cover
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Paperback. 72 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.This study aimed to evaluate the chemopreventive and antioxidative effects of Eleusine indica and Thysanolaena latifolia against CCl4-induced liver damage. Rats were pretreated with E. indica and T. latifolia for fourteen consecutive days prior to the administration of CCl4 (two doses). Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), glutathione (GSH), antioxidant enzymes and histopathological changes in rat liver were determined. Total phenolic content of E. indica and T. latifolia were found to be 14. 9 0. 002 and 20. 3 0. 007 mgg total phenolic expressed as gallic acid equivalent per gram of extract respectively. The extracts were able to reduce the stable DPPH in a dose dependent manner. The IC50 value for E. indica and T. latifolia were found to be 2350 gml and 1525 gml. However, most of these changes were alleviated by prophylactic treatment of animals with E. indica and T. latifolia dose dependently. We concluded that E. indica and T. latifolia could be used as hepatoprotective agents and possess the potential to be used to treat or prevent degenerative diseases where oxidative stress is implicated. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783846533857

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Bibliographic Details

Title: Liver Protective Effects of Eleusine Indica ...

Publisher: LAP LAMBERT Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

This study aimed to evaluate the chemopreventive and antioxidative effects of Eleusine indica and Thysanolaena latifolia against CCl4-induced liver damage. Rats were pretreated with E. indica and T. latifolia for fourteen consecutive days prior to the administration of CCl4 (two doses). Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), glutathione (GSH), antioxidant enzymes and histopathological changes in rat liver were determined. Total phenolic content of E. indica and T. latifolia were found to be 14.9 0.002 and 20.3 0.007 mg/g total phenolic expressed as gallic acid equivalent per gram of extract respectively. The extracts were able to reduce the stable DPPH in a dose dependent manner. The IC50 value for E. indica and T. latifolia were found to be 2350 g/ml and 1525 g/ml. However, most of these changes were alleviated by prophylactic treatment of animals with E. indica and T. latifolia dose dependently. We concluded that E. indica and T. latifolia could be used as hepatoprotective agents and possess the potential to be used to treat or prevent degenerative diseases where oxidative stress is implicated.

About the Author:

Dr. Iqbal, received his Ph.D. in biochemistry from India. He did his postdoctoral research from Canada, U.S.A., and Japan. His work involves free radicals, antioxidants and chemical carcinogenesis. He has published several articles in cited journals. Presently, Dr. Iqbal is working as an associate professor at University Malaysia Sabah.

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