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Mechanisms Underlying Cannabis Effects on the Brain

Aitziber Mendiguren

ISBN 10: 3659325252 / ISBN 13: 9783659325250
Published by LAP LAMBERT Academic Publishing
New Condition: New Paperback
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Paperback. 128 pages. Dimensions: 8.7in. x 5.9in. x 0.3in.Cannabinoid system regulates synaptic transmission in different brain regions. In this work, we study by electrophysiological techniques the effect of cannabinoids on the locus coeruleus (LC) and the dorsal raphe nucleus (DRN), the main noradrenergic and serotonergic nuclei in the central nervous system, respectively. These nuclei play a crucial role in the control of pain, mood, learningmemory, sleep-wake cycle, arousal and rewarding behavior. We demonstrate that cannabinoids alter the firing activity of LC cells and regulate glutamatergic system in this nucleus. We also describe how cannabinoids modulate GABAergic system in the DRN. In summary, our work shows that cannabinoids affect the neurons of the LC and DRN by a complex mechanism. The data of this study could explain why cannabis consumption results in a disruption of attention. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783659325250

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Bibliographic Details

Title: Mechanisms Underlying Cannabis Effects on ...

Publisher: LAP LAMBERT Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Cannabinoid system regulates synaptic transmission in different brain regions. In this work, we study by electrophysiological techniques the effect of cannabinoids on the locus coeruleus (LC) and the dorsal raphe nucleus (DRN), the main noradrenergic and serotonergic nuclei in the central nervous system, respectively. These nuclei play a crucial role in the control of pain, mood,learning/memory, sleep-wake cycle, arousal and rewarding behavior. We demonstrate that cannabinoids alter the firing activity of LC cells and regulate glutamatergic system in this nucleus. We also describe how cannabinoids modulate GABAergic system in the DRN. In summary, our work shows that cannabinoids affect the neurons of the LC and DRN by a complex mechanism. The data of this study could explain why cannabis consumption results in a disruption of attention.

About the Author:

BPharm, PhD. Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country (UPV/EHU). Her research has focused on studying pathophysiological and pharmacological mechanisms underlying the chronic use of psychoactive drugs such as cannabinoids and opioids. She is currently an associate professor at UPV/EHU.

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